Ginsenoside F4 (GF4), Ginsenoside, isolated from Panax notoginseng or red ginseng. Ginsenoside F4 (GF4) can inhibit human lymphocytic tumor JK cells by inducing apoptosis. Ginsenoside F4 (GF4) inhibited the expression of matrix metalloproteinase 13 (MMP 13) in IL-1β -treated chondrocytes, blocked cartilage damage in rabbit cartilage tissue culture, and prevented cartilage collagen matrix decomposition in pathological tissues.
| Molecular Weight | 766.99 |
| Formula | C42H70O12 |
| CAS Number | 181225-33-2 |
| Form | Solid |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Qi-le Zhou, et al. Chemical constituents of Chinese red ginseng
[2] Wen-Wen Shen, et al. Biotransformation of ginsenosides F 4 and Rg 6 in zebrafish
| Related Apoptosis Products |
|---|
| Cytochrome C (from Pig Heart)
Cytochrome C (from Pig Heart) is a multifunctional enzyme involved in cellular life and death decisions.Cytochrome C is critical in mitochondrial electron transport and intrinsic type II apoptosis. |
| Celosin K
Celosin K, a triterpenoid saponin isolated from the seeds of Semen Celosiae, is also a potent inhibitor of t-BHP-induced neuronal damage. In addition, Celosin K inhibits oxidative stress, apoptosis, and autophagy. |
| GLP-2(rat)
GLP-2(rat) is an intestinal growth factor. |
| Edratide
Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. |
| Thrombospondin-1 (1016-1023) (human, bovine, mouse)
Thrombospondin-1 (1016-1023) (human, bovine, mouse), is the C-terminal end of the native sequence of Thrombospondin-1 (TSP-1), is a CD47 agonist peptide. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
