About 30 results found for searched term "AR7" (0.01 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1662 | AZD8330 | MEK |
| ARRY-424704, ARRY-704 | ||
| AZD8330 (ARRY-424704) is a novel, selective, highly efficacious, uncompetitive MEK inhibitor with an IC50 of 7 nM. | ||
| M1705 | Erlotinib Hydrochloride | EGFR/HER2 |
| Tarceva, CP-358774, OSI-774, NSC-718781 | ||
| Erlotinib is an inhibitor of human EGFR tyrosine kinase (IC50 = 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC50 = 20 nM). | ||
| M1732 | Talazoparib (BMN-673) | PARP |
| BMN673; LT-673 | ||
| Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with Kis of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity. | ||
| M1776 | Rivaroxaban | Factor Xa |
| Xarelto, BAY 59-7939 | ||
| Rivaroxaban (Xarelto, BAY 59-7939) is oral direct factor Xa inhibitor with an IC50 value of 2.1nM. | ||
| M1811 | Tivantinib (ARQ-197) | c-Met |
| Tivantinib, ARQ197 | ||
| Tivantinib (ARQ 197) is a selective and oral small-molecule inhibitor of c-Met with a minimal IC50 value of 0.1 μM. | ||
| M1916 | Nelarabine | DNA/RNA Synthesis |
| Arranon, 506U78 | ||
| Nelarabine is a novel purine antimetabolite antineoplastic agent. | ||
| M2057 | Dexrazoxane hydrochloride | Topoisomerase |
| Cardioxane, ICRF-187, NSC169780, Zinecard，DXZ | ||
| Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity. | ||
| M2078 | SAR131675 | VEGFR/PDGFR |
| CAS#: 1092539-44-0 | ||
| SAR131675 is a potent and selective VEGFR-3 inhibitor with IC50 of 20 nM. | ||
| M2161 | SCH527123 | CXCR |
| Navarixin; MK-7123 | ||
| SCH527123 is a novel, selective CXCR2 receptor antagonist with IC50 of 3 nM. | ||
| M2215 | Niraparib (MK-4827) | PARP |
| MK-4827 | ||
| MK-4827 (Niraparib) is a selective PARP1/2 inhibitor with an IC50 value of 3.8 nM/2.1 nM that increases the formation of PARP-DNA complexes through inhibition of PARPase activity, leading to DNA damage, apoptosis, PARP-1-dependent cell death (parthanatos) and cell death. Strong effector activity when acting on cancer cells harboring mutant BRCA-1 and BRCA-2. It is more than 330-fold more selective than PARP3, V-PARP and Tank1. | ||
| M2227 | Imiquimod | Animal Modeling |
| Aldara, R 837; IMQ | ||
| Imiquimod (R837), an imidazoquinoline amine analog to guanosine, is a selective toll like receptor 7 (TLR7) agonist. with potent indirect antiviral activity. | ||
| M3699 | Letrozole | Animal Modeling |
| Femara; CGS 20267 | ||
| Letrozole is an orally active, potent, selective, nonsteroidal, third-generation aromatase (CYP19A1) inhibitor, a synthetic benzyltriazole derivative, which is used in the construction of animal models of polycystic ovary syndrome (PCOS), as well as in studies related to postoperative hormone-responsive breast cancer. | ||
| M3925 | Arctiin | Others |
| Arctii; NSC 315527; Arctigenin-4-glucoside | ||
| Arctiin is an active lignin isolated from Arctium lappa and has anti-inflammation, anti-microbial, and anti-carcinogenic effects. | ||
| M1621 | Ustekinumab | IL Receptor/Related |
| Anti-IL-12/IL-23,Stelara, CNTO 1275 | ||
| Ustekinumab is a human monoclonal antibody that targets IL12 and IL23, natural proteins that regulate the immune system and immune-mediated inflammatory diseases. | ||
| M1293 | Artesunate | STAT |
| WR-256283; ART; Armax 200; SM-804; HSDB-7458; AS | ||
| Artesunate is a potential STAT3 inhibitor that acts on the small cell lung cancer cell line H69 with an IC50 value of < 5 μM and is also used in antimalarial studies. Artesunate also promotes ROS signaling and lipid peroxidation by increasing the formation of variable iron pools, ultimately leading to iron death in pancreatic cancer cells. | ||
| M4786 | Aristolochic acid A | NF-κB |
| Aristolochic acid I; TR 1736 | ||
| Aristolochic acid A (Aristolochic acid I; TR 1736) is the principal component of the plant extract Aristolochic Acids, found in Aristolochia and Asarum herbs. Aristolochic acid A significantly decreased activator protein 1 (AP-1) and NF-κB activity. Aristolochic acid A reduces the expression of bladder cancer-associated BLCAP gene in human cells. | ||
| M4854 | BMN-673 8R,9S | PARP |
| Talazoparib (8R,9S); (8R,9S)-LT-673 | ||
| BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673.BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2. | ||
| M5343 | Voxtalisib Analogue | PI3K |
| SAR245409, XL765 | ||
| Voxtalisib (SAR245409, XL765) Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2. | ||
| M5477 | Carbazochrome sodium sulfonate (AC-17) | Adrenergic Receptor |
| AC-17 | ||
| Carbazochrome sodium sulfonate (AC-17) is an antihemorrhagic for use in the treatment of hemorrhoids. | ||
| M6151 | Larotrectinib (LOXO-101) | Trk |
| ARRY-470, larotrectinib | ||
| Larotrectinib (LOXO-101) is a potent, ATP competitive TRK inhibitor with IC50s in low nanomolar range for inhibition of all TRK family members in binding and cellular assays, with 100x selectivity over other kinases, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases. | ||
| M6155 | AR7 | RAR/RXR |
| AR-7 | ||
| AR7 is a retinoic acid receptor α (RARα) antagonist, it specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy. | ||
| M6158 | ARQ-087 | FGFR |
| Derazantinib | ||
| ARQ 087 is a novel, ATP competitive, small molecule, multi-kinase inhibitor with potent in vitro and in vivo activity against FGFR addicted cell lines and tumors. ARQ 087 exhibited IC50 values of 1.8 nM for FGFR2, and 4.5 nM for FGFR1 and 3. | ||
| M6170 | Bedaquiline fumarate | Antibiotic |
| R403323; TMC207 fumarate; R207910 fumarate | ||
| Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections. | ||
| M6211 | LOXO-101 sulfate | Trk |
| Larotrectinib sulfate; ARRY-470 sulfate | ||
| LOXO-101 sulfate is an oral potent and selective ATP-competitive inhibitor of tropomyosin receptor kinases (TRK). | ||
| M6462 | ARN272 | Others |
| ARN 272 | ||
| ARN272 is a fAAH-like anandamide transporter (FLAT) inhibitor. | ||
| M6464 | AR-R 17779 hydrochloride | Others |
| AR-R 17779 hydrochloride is a α7-selective agonist. | ||
| M6562 | Cardiogenol C hydrochloride | Others |
| Cardiogenol C HCl; CAS#: 671225-39-1 (free base) | ||
| Cardiogenol C hydrochloride is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 µM. | ||
| M7247 | SAR7334 dihydrochloride | Others |
| SAR 7334 2HCl | ||
| SAR7334 dihydrochloride is a novel, highly potent and bioavailable inhibitor of TRPC6 channels, inhibiting TRPC6 currents with IC50 of 7.9 nM. | ||
| M7912 | Mastoparan-7 | Others |
| Mastoparan 7 | ||
| G protein activator via Gαi and Gαo stimulation, similar to G protein-coupled receptors; peptide originally isolated from wasp venom. | ||
| M7913 | Mastoparan 17 | Others |
| Inactive analog of mastoparan; useful as negative control. | ||
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