About 30 results found for searched term "AK-1" (0.026 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1919 | Mubritinib | EGFR/HER2 |
| TAK-165 | ||
| Mubritinib (TAK-165) is a new potent inhibitor of human epidermal growth factor receptor 2 (HER2) tyrosine kinase (IC50 = 6 nM). | ||
| M2105 | Azilsartan medoxomil | Angiotensin Receptor |
| TAK-491 | ||
| Azilsartan Medoxomil is an effective angiotensin II Type 1 (AT1) receptor antagonist that inhibits RAAS more than 10,000 times more selectively than AT2, and is used to study hypertension. | ||
| M2154 | TAK-901 | Aurora Kinase |
| TAK901 | ||
| TAK-901 is a novel small-molecule inhibitor of Aurora A and Aurora B with IC50 of 21 nM and 15 nM. | ||
| M2581 | Ampalex | GluR |
| Ampakine CX516, BDP 12 | ||
| Ampalex is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). | ||
| M3048 | TAK-715 | p38 MAPK |
| TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. | ||
| M1545 | Infliximab | TNF Receptor |
| Remicade; Avakine; CT-P13 | ||
| Infliximab is a purified, recombinant DNA-derived chimeric human-mouse IgG monoclonal antibody that blocks TNF-α interaction with TNF-α receptor 1 (TNFR1) and TNFR2. For the treatment of autoimmune diseases. Infliximab is available in BALB/ C or C57/Bl6 mice. | ||
| M4888 | AC-6111 | Others |
| AKOS015899653, AN-36548 | ||
| M5291 | Sufugolix | LHRH/GnRH |
| TAK-013 | ||
| Sufugolix (TAK-013) is a highly potent and orally available luteinizing hormone-releasing hormone LHRH receptor antagonist with an IC50 of 0.1 nM. | ||
| M5347 | Y15 | FAK |
| FAK inhibitor Y15; FAK Inhibitor 14 | ||
| Y15 is a novel small molecule FAK phosphorylation inhibitor; specifically block phosphorylation of Y397-FAK and total phosphorylation of FAK. | ||
| M6175 | Serabelisib | PI3K |
| INK-1117,MLN-1117,TAK-117 | ||
| Serabelisib (INK-1117,MLN-1117,TAK-117) is a potent and selective oral PI3Kα isoform inhibitor (IC50 of 21 nmol/L against PI3Kα) that has demonstrated > 100-fold selectivity relative to other class I PI3K family members (PI3Kβ/γ/δ) and mTOR, and a high degree of selectivity against many other kinase. | ||
| M7068 | NVS PAK1 1 | Others |
| NVS PAK1 1 is a potent and selective PAK1 inhibitor. | ||
| M7349 | TAK 21d | Others |
| TAK 21d is a potent FAAH inhibitor. | ||
| M8500 | AK-1 | Sirtuin |
| AK-1 is a cell permeable, potent and specific SIRT2 inhibitor that induced proteasomal degradation of the Snail transcription factor. | ||
| M10227 | Pim1/AKK1-IN-1 | Pim |
| LKB1/AAK1 dual inhibitor | ||
| Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively. | ||
| M9197 | Relugolix | LHRH/GnRH |
| Orgovyx; TAK-385; RVT-601 | ||
| Relugolix, also known as TAK-385, is an orally active gonadotropin-releasing hormone (GnRH) antagonist with an IC50 of 0.12 nM. | ||
| M9340 | IRAK-1-4 Inhibitor I | IRAK |
| IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC50s of 0.3 μM and 0.2 μM, respectively. | ||
| M9528 | KPT-9274 | PAK |
| PAK4-IN-1 | ||
| KPT-9274, also known as PAK4-IN-1, is a potent, selective and dual PAK4/NAMPT inhibitor with IC50s of less than 100 and 120 nM, respectively. | ||
| M9634 | TAK-981 | E1/E2/E3 Enzyme |
| Subasumstat | ||
| TAK-981 is a first-in-class SUMO-activating enzyme inhibitor with superior immune activation and antitumor activity. | ||
| M9716 | AKOS B018304 | Others |
| AKOS B018304 is a potent inhibitor of chikungunya virus with low micro molar activity. | ||
| M9895 | LY3295668 | Aurora Kinase |
| AK-01 | ||
| LY3295668 (AK-01) is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. | ||
| M10169 | Vadadustat | HIF |
| AKB-6548; B-506; PG-1016548 | ||
| Vadadustat is a novel, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor. | ||
| M10682 | TAK-041 | GPR/FFAR |
| NBI-1065846 | ||
| TAK-041 is a first-in-class, selective GPR139 agonist with an EC50 of 22 nM. TAK-041 can be used to study negative symptoms of schizophrenia. | ||
| M13615 | Simurosertib | CDK |
| TAK-931 | ||
| Simurosertib (TAK-931) is an orally active, selective and ATP-competitive cell division cycle 7 (CDC7) kinase inhibitor, with an IC50 of <0.3 nM. Simurosertib has anti-cancer activity. | ||
| M14126 | Avatrombopag hydrochloride | Thrombopoietin/Thrombin |
| AKR-501 hydrochloride; E5501 hydrochloride; YM477 hydrochloride | ||
| Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. | ||
| M14832 | AKT-IN-1 | Akt |
| AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. | ||
| M14875 | PROTAC FAK degrader 1 | PROTAC |
| PROTAC FAK degrader 1 is a selective and potent von Hippel-Lindau-based focal adhesion kinase (FAK) degrader with an IC50 of 6.5 nM, DC50 of 3 nM. | ||
| M19896 | Acetylisovaleryltylosin Tartrate | Anti-infection |
| AK105039 | ||
| Acetylisovaleryltylosin tartrate is an antimicrobial of the macrolide group with antibacterial activity against Gram-positive bacteria. | ||
| M20001 | Testolactone | Others |
| sq9538;teolit;teslac;teslak;nsc-12173 | ||
| Testolactone was originally synthesized as a possible anabolic steroid. The key structural difference from anabolic steroids is the D-cyclolactone rather than the typical cyclopentyl ring. | ||
| M20671 | SGC-GAK-1 | CDK |
| SGC-GAK-1 is a potent, selective, and cell-active inhibitor of cyclin G-associated kinase (GAK) with Ki value of 3.1 nM and >50-fold selectivity over nearest kinase. | ||
| M20770 | AKR1C1-IN-1 | Others |
| AKR1C1-IN-1 is a potent and selective inhibitor of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with Ki of 4 nM, 87 nM, 4.2 μM and 18.2 μM for AKR1C1, AKR1C2, AKR1C3 and AKR1C4, respectively. | ||
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