About 30 results found for searched term "AK-1" (0.023 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1919 | Mubritinib | EGFR/HER2 |
| TAK-165 | ||
| Mubritinib (TAK-165) is a new potent inhibitor of human epidermal growth factor receptor 2 (HER2) tyrosine kinase (IC50 = 6 nM). | ||
| M2105 | Azilsartan medoxomil | Angiotensin Receptor |
| TAK-491 | ||
| Azilsartan Medoxomil is an effective angiotensin II Type 1 (AT1) receptor antagonist that inhibits RAAS more than 10,000 times more selectively than AT2, and is used to study hypertension. | ||
| M2154 | TAK-901 | Aurora Kinase |
| TAK901 | ||
| TAK-901 is a novel small-molecule inhibitor of Aurora A and Aurora B with IC50 of 21 nM and 15 nM. | ||
| M2581 | Ampalex | GluR |
| Ampakine CX516, BDP 12 | ||
| Ampalex is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator which can be used for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). | ||
| M3048 | TAK-715 | p38 MAPK |
| TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. | ||
| M1545 | Infliximab | TNF Receptor |
| Remicade; Avakine; CT-P13 | ||
| Infliximab is a purified, recombinant DNA-derived chimeric human-mouse IgG monoclonal antibody that blocks TNF-α interaction with TNF-α receptor 1 (TNFR1) and TNFR2. For the treatment of autoimmune diseases. Infliximab is available in BALB/ C or C57/Bl6 mice. | ||
| M4888 | AC-6111 | Others |
| AKOS015899653, AN-36548 | ||
| M5291 | Sufugolix | LHRH/GnRH |
| TAK-013 | ||
| Sufugolix (TAK-013) is a highly potent and orally available luteinizing hormone-releasing hormone LHRH receptor antagonist with an IC50 of 0.1 nM. | ||
| M5347 | Y15 | FAK |
| FAK inhibitor Y15; FAK Inhibitor 14 | ||
| Y15 is a novel small molecule FAK phosphorylation inhibitor; specifically block phosphorylation of Y397-FAK and total phosphorylation of FAK. | ||
| M6175 | Serabelisib | PI3K |
| INK-1117,MLN-1117,TAK-117 | ||
| Serabelisib (INK-1117,MLN-1117,TAK-117) is a potent and selective oral PI3Kα isoform inhibitor (IC50 of 21 nmol/L against PI3Kα) that has demonstrated > 100-fold selectivity relative to other class I PI3K family members (PI3Kβ/γ/δ) and mTOR, and a high degree of selectivity against many other kinase. | ||
| M7068 | NVS PAK1 1 | Others |
| NVS PAK1 1 is a potent and selective PAK1 inhibitor. | ||
| M7349 | TAK 21d | Others |
| TAK 21d is a potent FAAH inhibitor. | ||
| M8500 | AK-1 | Sirtuin |
| AK-1 is a cell permeable, potent and specific SIRT2 inhibitor with an IC50 of 12.5 μM, it induced proteasomal degradation of the Snail transcription factor. | ||
| M10227 | Pim1/AKK1-IN-1 | Pim |
| LKB1/AAK1 dual inhibitor | ||
| Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively. | ||
| M9197 | Relugolix | LHRH/GnRH |
| Orgovyx; TAK-385; RVT-601 | ||
| Relugolix, also known as TAK-385, is an orally active gonadotropin-releasing hormone (GnRH) antagonist with an IC50 of 0.12 nM. | ||
| M9340 | IRAK-1-4 Inhibitor I | IRAK |
| IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC50s of 0.3 μM and 0.2 μM, respectively. | ||
| M9528 | KPT-9274 | PAK |
| PAK4-IN-1 | ||
| KPT-9274, also known as PAK4-IN-1, is a potent, selective and dual PAK4/NAMPT inhibitor with IC50s of less than 100 and 120 nM, respectively. | ||
| M9634 | Subasumstat | E1/E2/E3 Enzyme |
| TAK-981 | ||
| Subasumstat (TAK-981) is a first-in-class SUMO-activating enzyme inhibitor with superior immune activation and antitumor activity. | ||
| M9716 | AKOS B018304 | Others |
| AKOS B018304 is a potent inhibitor of chikungunya virus with low micro molar activity. | ||
| M9895 | LY3295668 | Aurora Kinase |
| AK-01 | ||
| LY3295668 (AK-01) is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. | ||
| M10169 | Vadadustat | HIF |
| AKB-6548; B-506; PG-1016548 | ||
| Vadadustat is a novel, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor. | ||
| M10682 | TAK-041 | GPR/FFAR |
| NBI-1065846 | ||
| TAK-041 is a first-in-class, selective GPR139 agonist with an EC50 of 22 nM. TAK-041 can be used to study negative symptoms of schizophrenia. | ||
| M13615 | Simurosertib | CDK |
| TAK-931 | ||
| Simurosertib (TAK-931) is an orally active, selective and ATP-competitive cell division cycle 7 (CDC7) kinase inhibitor, with an IC50 of <0.3 nM. Simurosertib has anti-cancer activity. | ||
| M14126 | Avatrombopag hydrochloride | Thrombopoietin/Thrombin |
| AKR-501 hydrochloride; E5501 hydrochloride; YM477 hydrochloride | ||
| Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. | ||
| M14832 | AKT-IN-1 | Akt |
| AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. | ||
| M14875 | PROTAC FAK degrader 1 | PROTAC |
| PROTAC FAK degrader 1 is a selective and potent von Hippel-Lindau-based focal adhesion kinase (FAK) degrader with an IC50 of 6.5 nM, DC50 of 3 nM. | ||
| M19896 | Acetylisovaleryltylosin Tartrate | Anti-infection |
| AK105039 | ||
| Acetylisovaleryltylosin tartrate is an antimicrobial of the macrolide group with antibacterial activity against Gram-positive bacteria. | ||
| M20001 | Testolactone | Others |
| sq9538;teolit;teslac;teslak;nsc-12173 | ||
| Testolactone was originally synthesized as a possible anabolic steroid. The key structural difference from anabolic steroids is the D-cyclolactone rather than the typical cyclopentyl ring. | ||
| M20671 | SGC-GAK-1 | CDK |
| SGC-GAK-1 is a potent, selective, and cell-active inhibitor of cyclin G-associated kinase (GAK) with Ki value of 3.1 nM and >50-fold selectivity over nearest kinase. | ||
| M20770 | AKR1C1-IN-1 | Others |
| AKR1C1-IN-1 is a potent and selective inhibitor of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with Ki of 4 nM, 87 nM, 4.2 μM and 18.2 μM for AKR1C1, AKR1C2, AKR1C3 and AKR1C4, respectively. | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
