About 34 results found for searched term "50-21-5" (0.162 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M10385 | LC-2 | PROTAC |
| LC-2 is a potent first-in-class PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0.25 and 0.76 μM. | ||
| M13691 | Entasobulin | Microtubule |
| Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity. | ||
| M42700 | S1R agonist 2 | Sigma Receptor |
| S1R agonist 2 is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. | ||
| M54335 | GLP-1(28-36)amide | Glucagon Receptor |
| GLP-1(28-36)amide, a C-terminal nonapeptide of GLP-1, is a major product derived from the cleavage of GLP-1 by the neutral endopeptidase (NEP). | ||
| M1875 | PD173074 | FGFR |
| PD173074 is a selective FGFR1 and FGFR3 inhibitor with IC50 values of 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively. | ||
| M1987 | LY2886721 | BACE |
| LY2886721 is an effective, selective, orally active inhibitor of beta-site amyloid precursor protein lyase 1 (BACE1) with an IC50 of 20.3 nM against recombinant human BACE1. LY2886721 showed higher selectivity for BACE1 than cathepsin D, pepsin and renin, but lacked selectivity for BACE2 (IC50 was 10.2 nM). LY2886721 crosses the blood-brain barrier and can be used to study Alzheimer's disease. | ||
| M2040 | BAY 11-7082 | IκB/IKK |
| BAY 11-7821; NF-κB inhibitor 13 | ||
| BAY 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). | ||
| M2154 | TAK-901 | Aurora Kinase |
| TAK901 | ||
| TAK-901 is a novel small-molecule inhibitor of Aurora A and Aurora B with IC50 of 21 nM and 15 nM. | ||
| M2185 | Nutlin-3 | Mdm2 |
| Nutlin-3 is a selective MDM2 (mouse double minute 2) antagonist with IC50 of 90 nM. Nutlin-3 induces apoptosis in cancer cells. Nutlin-3 treatment induces the expression of MDM2 and p21, and displays potent antiproliferative activity with IC50 of ~1.5 μM in cells with wild-type p53 such as HCT116, RKO and SJSA-1. | ||
| M55629 | MIPS-21335 | PI3K |
| MIPS21335 | ||
| MIPS-21335 is a PI3KC2α inhibitor, with IC50 of 7 nM. MIPS-21335 also inhibits PI3KC2β, p110α, p110β and p110δ with IC50 values of 0.043, 0.140, 0.386, 0.742 μM, respectively. | ||
| M3063 | TG100713 | PI3K |
| TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively. | ||
| M3194 | Nocodazole | Src-bcr-Abl |
| Oncodazole；R17934 | ||
| Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. | ||
| M3486 | NPS-2143 | Calcium-sensing Receptor |
| SB262470 | ||
| NPS-2143 is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor. | ||
| M3504 | BS-181 hydrochloride | CDK |
| BS-181 HCl | ||
| BS-181 is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. | ||
| M3802 | GF 109203X | PKC |
| GO 6850; Bisindolylmaleimide I | ||
| GF 109203X is a very potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). | ||
| M4583 | (-)-Maackiain | Parasite |
| l-Maackiain | ||
| Maackiain (DL-Maackiain) was separated from Maackia amurensis Rupr. Et Maxim. Maackiain (DL-Maackiain) is a larval insecticide against Aedes aegypti with a LD50 of 21.95 μg/ mL. Maackiain (DL-Maackiain) induces DNA fragmentation into oligonucleosome size fragments, similar to apoptotic characteristics such as HL-60 cells. | ||
| M4933 | CC-115 | DNA-PK |
| CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). CC-115 inhibits PC-3 cells proliferation with an IC50 of 138 nM. CC-115 blocks both mTORC1 and mTORC2 signaling. | ||
| M43838 | Almonertinib mesylate | EGFR/HER2 |
| HS-10296 mesylate | ||
| Almonertinib mesylate is an orally active, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR sensitization and T790M resistance mutations, and also shows strong inhibitory activity against T790M, T790M/L858R, and T790M/Del19, with IC50 of 0.37, 0.29, and 0.21 nM, respectively. The IC50 of T790M/Del19 was 0.37, 0.29 and 0.21 nM, respectively, but the inhibitory effect on wild-type was weaker, with an IC50 of 3.39 nM. It can be used in the research of non-small cell lung cancer. | ||
| M6843 | JK184 | Hedgehog |
| JK184 is a potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). JK184 exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. JK184 inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro. | ||
| M8529 | A-366 | Histone Methyltransferase |
| A366 | ||
| A-366 is a potent and highly selective peptide-competitive inhibitor of histone methyltransferase G9a, with IC50s of 3.3 nM and 38 nM for G9a and GLP, respectively, and is more than 1,000-fold selective for G9a and GLP over 21 other methyltransferases. A-366 is also a potent inhibitor of Spindlin1-H3K4me3 interaction (IC50=182.6 nM).A-366 shows high affinity for human H3R (Ki=17 nM) and exhibits subtype selectivity between subpopulations of the histaminergic and dopaminergic receptor families. It can be used for induction and maintenance of pluripotent stem cells in mice. | ||
| M8850 | WAY-213613 | EAAT |
| Way-213613 is a potent, selective, non-substrate reuptake inhibitor of GLT-1/EAAT2 with an IC50 of 85 nM against EAAT2. The selectivity of WAY-213613 hydrochloride to EAAT1 and EAAT3 was 59 and 44 times higher (IC50 was 5 and 3.8 μM, respectively). Way-213613 has no activity on ionic and metabolic glutamate receptors. | ||
| M8938 | FIIN-3 | FGFR |
| FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor with IC50 values of 13.1, 21, 31.4 and 35.3 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. | ||
| M10531 | BRD3731 | GSK-3 |
| BRD3731 is a selective GSK3β inhibitor, with IC50s of 15 nM and 215 nM for GSK3β and GSK3α, respectively. | ||
| M10702 | AZD5582 | IAP |
| AZD5582 is an IAP antagonist that can be effectively combined with bir3 domains of cIAP1, cIAP2, and XIAP, IC50 The values are 15, 21, 15 nM, respectively. AZD5582 Induces apoptosis. | ||
| M11097 | Uralenol | Phosphatase |
| Uralenol is a natural PTP1B inhibitor (IC50=21. 5 μM) from Broussonetia papyrifera. In many cellular and biochemical studies, PTP1B have been shown to play a major role in the dephosphorylation of the insulin receptor. | ||
| M11493 | Recombinant Human SCF (P. pastoris) | Cytokines and Growth Factors |
| Kit ligand; C-Kit Ligand; Mast Cell Growth Factor | ||
| The recombinant human SCF protein stimulated TF-1 cells dose-dependent, ED50 < 2.0 ng/ mL, and corresponding specific activity was 5 × 10< SUP > 5IU/mg. Protein structure: Coexpressed with n-terminal methionine. Accession # : P21583-1. | ||
| M13618 | XL413 hydrochloride | CDK |
| BMS-863233 hydrochloride | ||
| XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC50 of 3.4 nM, and also shows potent effect with IC50s of 215, 42 nM on CK2, PIM1, respectively, and an EC50 of 118 nM on pMCM. | ||
| M13656 | CC-115 hydrochloride | DNA-PK |
| CC-115 hydrochloride is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling. | ||
| M13684 | VER-50589 | HSP |
| VER-50589 is a Hsp90 inhibitor, with an IC50 of 21 nM and a Kd of 4.5 nM. | ||
| M14085 | PF-06928215 | Others |
| PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM (Kd). | ||
| M14423 | GSK2256294A | Epoxide Hydrolase |
| GSK 2256294 | ||
| GSK2256294A is a potent, reversible, tight binding inhibitor of isolated recombinant human sEH (soluble epoxide hydrolase) (IC50 = 27 pM; t1/2 = 121 min) and displays potent inhibition against the rat (IC50 = 61 pM) and murine (IC50 = 189 pM) orthologs of sEH. | ||
| M14425 | LY2183240 | FAAH |
| LY2183240 is a highly potent blocker of anandamide uptake (IC50= 270 pM; Ki=540 nM). LY2183240 is a potent, covalent inhibitor of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) with an IC50 of 12.4 nM. | ||
| M20997 | Remogliflozin etabonate (GSK189075) | SGLT |
| Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity inhibitor of sodium glucose cotransporter (SGLT2) with Ki of 1950 nM, 2140 nM, 43100 nM, 8570 nM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models. | ||
| M21136 | ABD957 | MAGL |
| ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, inhibiting IC50 at an IC50 of 0.21 µM. ABD957 impaired N-Ras depalmitylation in AML cells, reducing N-Ras signaling and the growth of NRAS mutant AML cells. | ||
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