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Way-213613 is a potent, selective, non-substrate reuptake inhibitor of GLT-1/EAAT2 with an IC50 of 85 nM against EAAT2. The selectivity of WAY-213613 hydrochloride to EAAT1 and EAAT3 was 59 and 44 times higher (IC50 was 5 and 3.8 μM, respectively). Way-213613 has no activity on ionic and metabolic glutamate receptors.
| Molecular Weight | 415.19 |
| Formula | C16H13BrF2N2O4 |
| CAS Number | 868359-05-1 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related EAAT Products |
|---|
| L-threo-3-Hydroxyaspartic acid
L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines. |
| cis-α-(Carboxycyclopropyl)glycine
cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. |
| Troriluzole Hydrochloride
Troriluzole Hydrochloride is the hydrochloride form of Troriluzole, and is also an excitatory amino acid transporter protein 2 (EAAT2) modulator, which increases glutamate uptake at neuronal synapses by increasing the expression of EAAT in neuroglia and enhancing its function, thereby decreasing glutamate levels in neuronal synapses. It can be used in studies related to spinocerebellar ataxia (SCA) and anxiety disorders. |
| Trigriluzole
Trigriluzole is an excitatory amino acid transporter protein 2 (EAAT2) modulator that increases the uptake of glutamate at neuronal synapses by increasing the expression and enhancing the function of EAAT in glial cells, thereby decreasing glutamate levels in neuronal synapses. It can be used in studies related to spinocerebellar ataxia (SCA) and anxiety disorders. |
| TFB-TBOA
TFB-TBOA (CF3-Bza-TBOA) is a potent glutamate transporter blocker that potently suppresses the activity of glial transporters. TFB-TBOA shows IC50 values of 22, 17, and 300 nM for glutamate transporters EAAT1, EAAT2, and EAAT3 respectively in an uptake assay using cells transiently expressing EAATs. |
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