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DL-TBOA

Cat. No. M10023
DL-TBOA Structure
Synonym:

DL-Threo-Beta-Benzyloxyaspartic acid

Size Price Availability
5mg USD 500  USD500 1-2 Weeks
10mg USD 900  USD900 1-2 Weeks
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Quality Control & Documentation
Biological Activity

DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively.

Chemical Information
Molecular Weight 239.22
Formula C11H13NO5
CAS Number 205309-81-5
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Elena Pedraz-Cuesta, et al. BMC Cancer. The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells

[2] Y Shigeri, et al. J Neurochem. Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5)

[3] K Shimamoto, et al. Mol Pharmacol. DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters

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  Catalog
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Keywords: DL-TBOA, DL-Threo-Beta-Benzyloxyaspartic acid supplier, EAAT, inhibitors, activators


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