All AbMole products are for research use only, cannot be used for human consumption.
CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). CC-115 inhibits PC-3 cells proliferation with an IC50 of 138 nM. CC-115 blocks both mTORC1 and mTORC2 signaling. The IC50 values for CC-115 are >10 μM against a panel of CYP enzymes and >33 μM for the hERG ion channel. When screened in a single point assay at 10 μM against a Cerep receptor and enzyme panel only one target was inhibited >50% (PDE3, IC50 = 0.63 μM).
| Molecular Weight | 336.35 |
| Formula | C16H16N8O |
| CAS Number | 1228013-15-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 17 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related DNA-PK Products |
|---|
| Nedisertib
Nedisertib (M3814) is a potent, orally available and selective inhibitor of DNA-PK, with an IC50 of <3 nM. |
| BAY-8400
BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50=81 nM). |
| ZL-2201
ZL-2201 is a potent DNA-PK inhibitor with an IC50 of 1 nM. |
| AMA-37
AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively. |
| PIK-75
PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM). PIK-75 induces apoptosis. |
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Products are for research use only. Not for human use. We do not sell to patients.
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