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DNA-PK DNA-dependent protein kinase

Cat.No.  Name Information
M13657 VX-984 VX-984 is a potent DNA-PK inhibitor.
M9341 AZD-7648 AZD-7648 is a potent and selective DNA-PK inhibitor.
M6284 Compound 401 Compound 401 is a synthetic inhibitor of DNA-PK (IC50 = 0.28 μM) that also targets mTOR but not PI3K in vitro.
M6205 YU238259 YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.
M6077 LTURM34 LTURM34 is a specific DNA-PK inhibitor, 170-fold more selective for DNA-PK activity compared to PI3K activity, with IC50 value of 0.034 μM.
M4933 CC-115 CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). CC-115 inhibits PC-3 cells proliferation with an IC50 of 138 nM. CC-115 blocks both mTORC1 and mTORC2 signaling.
M2798 KU-0060648 KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM.
M2308 NU7026 NU7026 is a DNA-PK inhibitor with IC50 of 0.23 μM.
M41474 ZL-2201 ZL-2201 is a potent DNA-PK inhibitor with an IC50 of 1 nM.
M30049 AMA-37  AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively.
M30008 PIK-75  PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM). PIK-75 induces apoptosis.
M21187 BAY-8400 The DNA-PK inhibitor BAY-8400 is an orally active and selective inhibitor of DNA-PK kinase that synergistically enhances the efficacy of radiotherapeutic agents in xenograft models.
M13658 STL127705 STL127705 (Compound L) is a Ku 70/80 heterodimer protein inhibitor, inhibits Ku70/80-DNA interaction, with an IC50 of 3.5 μM. STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5 μM).
M13656 CC-115 hydrochloride CC-115 hydrochloride is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.

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