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NU7026

Cat. No. M2308
NU7026 Structure
Synonym:

LY293646

Size Price Availability Quantity
5mg USD 55  USD55 In stock
10mg USD 80  USD80 In stock
50mg USD 320  USD320 In stock
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Quality Control
Biological Activity

NU7026 is a DNA-PK inhibitor with IC50 of 0.23 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 281.31
Formula C17H15NO3
CAS Number 154447-35-5
Purity 99.65%
Solubility DMSO 2 mg/mL (May need ultrasonic)
Storage at -20°C
References

[1] Dmitry Kostyushev, et al. Suppressing the NHEJ pathway by DNA-PKcs inhibitor NU7026 prevents degradation of HBV cccDNA cleaved by CRISPR/Cas9

[2] M T Niazi, et al. Effects of dna-dependent protein kinase inhibition by NU7026 on dna repair and cell survival in irradiated gastric cancer cell line N87

[3] Lilian Amrein, et al. Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase

[4] B P Nutley, et al. Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026

[5] Elaine Willmore, et al. A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia

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  Catalog
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Keywords: NU7026, LY293646 supplier, DNA-PK, inhibitors

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