About 27 results found for searched term "DNA-PK" (0.156 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43294 | DNA-PK Substrate | Others |
| DNA-PK Substrate is a biological active peptide. | ||
| M1773 | PI-103 | PI3K |
| PI103 | ||
| PI-103 is a potent, ATP-competitive PI3K,cell-permeable,inhibitor.The IC50 values are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γrespectively. | ||
| M1801 | KU-55933 | ATM/ATR |
| KU55933 | ||
| KU-55933 is a cell-permeable ATP-competitive inhibitor of ATM (IC50 = 13 nM; Ki = 2.2 nM) with selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 μM for DNAPK, mTOR, PI 3-K, respectively; IC50 > 100 μM for PI 4-K and ATR). | ||
| M1809 | NU7441 | PI3K |
| KU 57788 | ||
| NU7441 (KU 57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 values of 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively. | ||
| M1849 | Voxtalisib (XL765) | PI3K |
| SAR245409 | ||
| Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2. | ||
| M1925 | LY294002 | PI3K |
| NSC 697286; SF 1101 | ||
| LY294002 is a highly selective PI3K inhibitor with IC50 values of 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively. LY294002 also inhibits CK2 with an IC50 of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. | ||
| M2187 | ETP-46464 | ATM/ATR |
| ETP-46464 is a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα and ATM with IC50 of 0.6, 14, 36, 170 and 545 nM, respectively. | ||
| M2308 | NU7026 | DNA-PK |
| LY293646 | ||
| NU7026 is a DNA-PK inhibitor with IC50 of 0.23 μM. | ||
| M2798 | KU-0060648 | DNA-PK |
| KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM. | ||
| M2893 | NU6027 | CDK |
| NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors. | ||
| M4933 | CC-115 | DNA-PK |
| CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). | ||
| M5337 | PI-3065 | PI3K |
| PI-3065 is a novel potent and selective PI3K p110δ inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110α, p110β, p110γ, DNA-PK and mTOR | ||
| M5343 | Voxtalisib Analogue | PI3K |
| SAR245409, XL765 | ||
| Voxtalisib (SAR245409, XL765) Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2. | ||
| M6077 | LTURM34 | DNA-PK |
| LTURM34 is a specific DNA-PK inhibitor, 170-fold more selective for DNA-PK activity compared to PI3K activity, with IC50 value of 0.034 μM. | ||
| M6152 | SF2523 | PI3K |
| SF2523 is a highly selective and potent inhibitor of PI3K with IC50 values of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively. | ||
| M6284 | Compound 401 | DNA-PK |
| Compound 401 is a synthetic inhibitor of DNA-PK (IC50 = 0.28 μM) that also targets mTOR but not PI3K in vitro. | ||
| M6721 | ETP 45658 | Others |
| ETP 45658 is a potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTOR. | ||
| M8925 | LY3023414 | PI3K |
| LY3023414 is a selective ATP-competitive inhibitor of PI3Kα and mTOR, DNA-PK, and other class I PI3K family members. | ||
| M9341 | AZD-7648 | DNA-PK |
| AZD-7648 is a potent and selective DNA-PK inhibitor. | ||
| M11017 | Camonsertib (RP-3500) | ATM/ATR |
| ATR inhibitor 4; Camonsertib | ||
| Camonsertib (RP-3500) is an orally potent, selective ATR kinase inhibitor (ATRi) in biochemical assays IC50 1.00 nM. The RP-3500 is 30 times more selective to ATR (IC).50=120 nM), which is 2,000 times > ATM, DNA-PK, and PI3Kα kinase. | ||
| M13656 | CC-115 hydrochloride | DNA-PK |
| CC-115 hydrochloride is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling. | ||
| M13657 | VX-984 | DNA-PK |
| VX-984 is a potent DNA-PK inhibitor. | ||
| M13658 | STL127705 | DNA-PK |
| STL127705 (Compound L) is a Ku 70/80 heterodimer protein inhibitor, inhibits Ku70/80-DNA interaction, with an IC50 of 3.5 μM. STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5 μM). | ||
| M21187 | BAY-8400 | DNA-PK |
| The DNA-PK inhibitor BAY-8400 is an orally active and selective inhibitor of DNA-PK kinase that synergistically enhances the efficacy of radiotherapeutic agents in xenograft models. | ||
| M30008 | PIK-75 | DNA-PK |
| PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM). PIK-75 induces apoptosis. | ||
| M30049 | AMA-37 | DNA-PK |
| AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively. | ||
| M41474 | ZL-2201 | DNA-PK |
| ZL-2201 is a potent DNA-PK inhibitor with an IC50 of 1 nM. | ||
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