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Nedisertib (M3814) is a potent, orally available and selective inhibitor of DNA-PK, with an IC50 of <3 nM.
Molecular Weight | 481.91 |
Formula | C24H21ClFN5O3 |
CAS Number | 1637542-33-6 |
Form | Solid |
Solubility (25°C) | DMSO 50 mg/mL |
Storage | -20°C, protect from light, sealed |
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BAY-8400
BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50=81 nM). |
ZL-2201
ZL-2201 is a potent DNA-PK inhibitor with an IC50 of 1 nM. |
AMA-37
AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively. |
PIK-75
PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM). PIK-75 induces apoptosis. |
BAY-8400
The DNA-PK inhibitor BAY-8400 is an orally active and selective inhibitor of DNA-PK kinase that synergistically enhances the efficacy of radiotherapeutic agents in xenograft models. |
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