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PF-06928215

Cat. No. M14085

All AbMole products are for research use only, cannot be used for human consumption.

PF-06928215 Structure
Size Price Availability Quantity
1mg USD 90  USD90 In stock
5mg USD 225  USD225 In stock
10mg USD 345  USD345 In stock
25mg USD 620  USD620 In stock
50mg USD 900  USD900 In stock
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Quality Control & Documentation
Biological Activity

PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM (Kd).

Chemical Information
Molecular Weight 380.4
CAS Number 2378173-15-8
Form Solid
Solubility (25°C) DMSO 33.33 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yan Gong, et al. Double knockout of Akt2 and AMPK accentuates high fat diet-induced cardiac anomalies through a cGAS-STING-mediated mechanism

[2] Wenfeng Zhao, et al. In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing

[3] Justin Hall, et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay

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Keywords: PF-06928215 supplier, inhibitors, activators

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