About 18 results found for searched term "4-MDM" (0.406 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8268 | 4-MDM | Others |
| 4-MDM augments the aminopeptidase activity of LTA4 hydrolase without affecting the conversion of LTA4 to LTB4. | ||
| M3628 | RG7112 | Mdm2 |
| RO5045337 | ||
| RG7112 (RO5045337) is the first-in-class small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2. | ||
| M6164 | MCC950 | Pyroptosis |
| CP-456773 | ||
| MCC950 (CP-456773) is a potent, selective NLRP3 inhibitor with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively. | ||
| M6301 | SAR405838 | Mdm2 |
| MI-773 | ||
| MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. | ||
| M8083 | MCC950 sodium salt (CP-456773) | Pyroptosis |
| CP-456773 sodium; CRID3 sodium salt | ||
| MCC950 (CP-456773) sodium salt is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. MCC950 specifically inhibits NLRP3 but not AIM2, NLRC4 or NLRP1 activation. | ||
| M9184 | RO8994 | Mdm2 |
| RO-8994 | ||
| RO8994 is a potent and selective spiroindolinone MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays). | ||
| M10690 | Sulanemadlin (ALRN6924) | p53 |
| ALRN-6924; MP-4897 | ||
| ALRN-6924 is a stapled peptide that blocks interactions between p53 and both MDM2 and MDMX. | ||
| M14872 | MD-224 | PROTAC |
| MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. | ||
| M21141 | GNE-6640 | Deubiquitinase |
| GNE-6640 is a selective, non-covalently bound inhibitor of ubiquitin-specific peptidase 7 (USP7) with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for USP7 full-length, USP7 catalytic domain, USP43 full-length and Ub-MDM2, respectively. | ||
| M28049 | SP-141 | p53 |
| SP-141 is a specific inhibitor of MDM2. SP-141 promotes MDM2 auto-ubiquitination and degradation. SP-141 might be used for the research of pancreatic cancer and breast cancer cells. | ||
| M38925 | Ivaltinostat | HDAC |
| Ivaltinostat (CG-200745) is an orally active, potent pan-HDAC inhibitor which inhibits deacetylation of histone H3 and tubulin. Ivaltinostat induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. | ||
| M40517 | MK8242 | Mdm2 |
| MK8242 is a small molecule MDM2 inhibitor that stabilizes the tumor suppressor TP53 and can be used in studies related to acute myeloid leukemia and solid tumors. | ||
| M41349 | MDMX/MDM2-IN-2 | Mdm2 |
| MDMX/MDM2-IN-2 is a potent p53-MDM2/MDMX dual inhibitors with Kis of 0.23 μM and 2.45 μM for MDM2 and MDMX, respectively. | ||
| M41351 | YL93 | Mdm2 |
| YL93 is a dual inhibitors of MDM2/4 with Ki values of 0.64 μM and 1.1 nM for MDM4 and MDM2, respectively. | ||
| M41352 | UNP-6457 | Mdm2 |
| UNP-6457 is a potent active MDM2-p53 interaction inhibitor with an IC50 values of 8.9 nM. | ||
| M41356 | MMRi64 | Mdm2 |
| MMRi64 disrupts Mdm2-MdmX interactions. | ||
| M42879 | MEL24 | Others |
| MEL24 is an Mdm2 E3 ligase inhibitor that reduces cell survival and increases sensitivity to DNA damaging agents in a p53-dependent manner for in vitro antitumor studies. | ||
| M54573 | NLRP3-IN-NBC6 | NLR |
| NLRP3-IN-NBC6 is a potent and selective NLRP3 inflammatory vesicle inhibitor (IC50= 574 nM) that acts independently of Ca2+.NLRP3-IN-NBC6 inhibits Nigericin-induced inflammatory responses in THP-1 cells and Imiquimod-induced LPS-primed bone marrow-derived macrophages ( BMDMs) release of IL-1β. | ||
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