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SAR405838

Cat. No. M6301

All AbMole products are for research use only, cannot be used for human consumption.

SAR405838 Structure

Synonym:

MI-773

Size	Price	Availability
5mg	USD 215 USD215	Custom Synthesis
10mg	USD 360 USD360	Custom Synthesis
25mg	USD 800 USD800	Custom Synthesis

Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation

Purity: >99.0%
COA
MSDS

Product Information

Biological Activity

MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM.

Chemical Information

Molecular Weight	562.50
Formula	C29H34Cl2FN3O3
CAS Number	1303607-60-4
Solubility (25°C)	100 mg/mL in DMSO
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

References

[1] Kate Lynn J Bill, et al. Correction: SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma

[2] Minjee Kim, et al. Brain Distributional Kinetics of a Novel MDM2 Inhibitor SAR405838: Implications for Use in Brain Tumor Therapy

[3] Shaomeng Wang, et al. Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapy: Progress and Challenges

[4] Kate Lynn J Bill, et al. SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma

[5] Shaomeng Wang, et al. SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression

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UNP-6457 UNP-6457 is a potent active MDM2-p53 interaction inhibitor with an IC50 values of 8.9 nM.
YL93 YL93 is a dual inhibitors of MDM2/4 with Ki values of 0.64 μM and 1.1 nM for MDM4 and MDM2, respectively.

Catalog

Abmole Inhibitor Catalog

Keywords: SAR405838, MI-773 supplier, Mdm2, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.

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