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Mdm2 Murine Double Minute 2

Inhibitors

Cat.No.  Name Information
M3628 RG7112 RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.
M2185 Nutlin-3 Nutlin-3 is a selective MDM2 (mouse double minute 2) antagonist with IC50 of 90 nM.
M21506 MD-222 MD-222 is a first-in-class, highly effective ProTAC-based MDM2 depressant. MD-222 has anti-cancer properties.
M20600 YH239-EE YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
M13439 Milademetan Milademetan (DS-3032) is a specific, orally active MDM2 inhibitor for the study of acute myeloid leukemia and solid tumors.
M13393 NVP-CGM097 NVP-CGM097 is a highly effective and selective MDM2 inhibitor with a Ki value of 1.3 nM.
M11331 UC2288 UC2288 is a novel p21 attenuator with cellular permeability and oral activity (relatively selective activity for P21), based on the structural synthesis of sorafenib (HY-10201). UC2288 down-regulated the expression of P21 mRNA and reduced the level of P21 protein independently of p53, and had little effect on the stability of P21 protein. UC2288 did not inhibit VEGFR2 and Raf kinases, even at 10 μM.
M10374 AMG 232 AMG 232 is an extremely potent MDM2 inhibitor (SPR KD = 0.045 nM, SJSA-1 EdU IC50 = 9.1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model (ED50 = 9.1 mg/kg). *The compound is unstable in solutions, freshly prepared is recommended
M9184 RO8994 RO8994 is a potent and selective spiroindolinone MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).
M8895 MX69 MX69 is a dual inhibitor of MDM2 and XIAP that binds to MDM2 RING protein with binding Kd values of 2.34 μM.
M8014 Cyclic Pifithrin-α hydrobromide A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity.
M7535 HDM201 HDM201 is a novel, highly potent and selective inhibitor of the p53-Mdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than 10000-fold vs Mdm4.
M6290 Puromycin aminonucleoside Puromycin aminonucleoside is the aminonucleoside portion of the antibiotic puromycin, and a puromycin analog which does not inhibit protein synthesis or induce apoptosis.
M5700 Idasanutlin (RG-7388) Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity.
M5225 MI-773 MI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM.
M5004 Kevetrin hydrochloride Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
M4265 Peimisine Peimisine (Ebeiensine) noncompetitively antagonizes M receptors in tracheal smooth muscle and thus inhibits Ach induced smooth muscle contraction. Peimisine also stimulates beta receptors and antagonizes the release of calcium, promoting the release of NO and thus relaxing the smooth muscles of the trachea to achieve antiasthmatic effects.
M3628 RG7112 RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.
M3224 NSC 207895 NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
M3014 SL-01 SL-01 is a p53-Mdm2 interaction inhibitor with IC50 of 3.18 μM.
M2895 Nutlin-3b Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite enantiomer Nutlin-3a.
M2894 Nutlin-3a Nutlin-3a, the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM.



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