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NVP-CGM097 is a highly effective and selective MDM2 inhibitor with a Ki value of 1.3 nM. In wild-type p53 cells, NVP-CGM097 significantly induced p53 reassignment into the nucleus with IC50 of 0.224 μM. Nvp-cgm097 inhibited HCT116 (p53WT/WT) cells with IC50 of 454 ± 136 nM.
| Molecular Weight | 659.26 |
| Formula | C38H47ClN4O4 |
| CAS Number | 1313363-54-0 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Mdm2 Products |
|---|
| MMRi64
MMRi64 disrupts Mdm2-MdmX interactions. |
| MeOIstPyrd
MeOIstPyrd is an anti-skin cancer agent. |
| MDM2/XIAP-IN-3
MDM2/XIAP-IN-3 is a dual MDM2/XIAP inhibitor. |
| UNP-6457
UNP-6457 is a potent active MDM2-p53 interaction inhibitor with an IC50 values of 8.9 nM. |
| YL93
YL93 is a dual inhibitors of MDM2/4 with Ki values of 0.64 μM and 1.1 nM for MDM4 and MDM2, respectively. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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