| Cat.No. | Name | Information |
|---|---|---|
| M3628 | RG7112 | RG7112 (RO5045337) is the first-in-class small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2. |
| M2185 | Nutlin-3 | Nutlin-3 is a selective MDM2 (mouse double minute 2) antagonist with IC50 of 90 nM. |
| M2894 | Nutlin-3a | Nutlin-3a, the active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM). Nutlin-3a inhibits the p53/MDM2 interaction with IC50 of 90 nM. |
| M41356 | MMRi64 | MMRi64 disrupts Mdm2-MdmX interactions. |
| M41355 | MeOIstPyrd | MeOIstPyrd is an anti-skin cancer agent. |
| M41354 | MDM2/XIAP-IN-3 | MDM2/XIAP-IN-3 is a dual MDM2/XIAP inhibitor. |
| M41352 | UNP-6457 | UNP-6457 is a potent active MDM2-p53 interaction inhibitor with an IC50 values of 8.9 nM. |
| M41351 | YL93 | YL93 is a dual inhibitors of MDM2/4 with Ki values of 0.64 μM and 1.1 nM for MDM4 and MDM2, respectively. |
| M41350 | MDM2/XIAP-IN-2 | MDM2/XIAP-IN-2 is a dual inhibitor of murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). |
| M41349 | MDMX/MDM2-IN-2 | MDMX/MDM2-IN-2 is a potent p53-MDM2/MDMX dual inhibitors with Kis of 0.23 μM and 2.45 μM for MDM2 and MDMX, respectively. |
| M40973 | MI-219 | MI-219 is a potent, highly selective, orally active MDM2 inhibitor that effectively blocks the interaction of MDM2 with p53 (Ki=5nM), and its selectivity for MDM2 is 10,000 times higher than that of MDMX, which has anticancer activity. |
| M40517 | MK8242 | MK8242 is a small molecule MDM2 inhibitor that stabilizes the tumor suppressor TP53 and can be used in studies related to acute myeloid leukemia and solid tumors. |
| M21647 | MB710 | MB710 is a stabilizer of oncogenic p53 mutation Y220C. MB710 binds tightly to the Y220C pocket and stabilizes p53-Y220C, with a Kd of 4.1 μM. MB710 shows anticancer activity in p53-Y220C cell lines. |
| M20600 | YH239-EE | YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer. |
| M13553 | Milademetan tosylate hydrate | Milademetan (DS-3032) tosylate hydrate is a specific and orally active MDM2 inhibitor for the research of acute myeloid leukemia (AML) or solid tumors. |
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