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MI-219 is a potent, highly selective, orally active MDM2 inhibitor that effectively blocks the interaction of MDM2 with p53 (Ki=5nM), and its selectivity for MDM2 is 10,000 times higher than that of MDMX, which has anticancer activity.
| Molecular Weight | 552.47 |
| Formula | C27H32Cl2FN3O4 |
| CAS Number | 908027-55-4 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Mdm2 Products |
|---|
| MMRi64
MMRi64 disrupts Mdm2-MdmX interactions. |
| MeOIstPyrd
MeOIstPyrd is an anti-skin cancer agent. |
| MDM2/XIAP-IN-3
MDM2/XIAP-IN-3 is a dual MDM2/XIAP inhibitor. |
| UNP-6457
UNP-6457 is a potent active MDM2-p53 interaction inhibitor with an IC50 values of 8.9 nM. |
| YL93
YL93 is a dual inhibitors of MDM2/4 with Ki values of 0.64 μM and 1.1 nM for MDM4 and MDM2, respectively. |
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