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MDMX/MDM2-IN-2 is a potent p53-MDM2/MDMX dual inhibitors with Kis of 0.23 μM and 2.45 μM for MDM2 and MDMX, respectively.
| Molecular Weight | 576.87 |
| Formula | C28H25Cl3FN3O3 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Christine M Eischen. J Mol Cell Biol. Role of Mdm2 and Mdmx in DNA repair
[4] Orit Karni-Schmidt et al. Annu Rev Pathol. The Roles of MDM2 and MDMX in Cancer
[5] Mark Wade et al. Nat Rev Cancer. MDM2, MDMX and p53 in oncogenesis and cancer therapy
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