| Cat.No. | Name | Information |
|---|---|---|
| M3386 | Amiloride hydrochloride | Amiloride hydrochloride, a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. |
| M3366 | Amiloride hydrochloride dihydrate | Amiloride Hydrochloride Dihydrate (MK-870 Hydrochloride Dihydrate) is an inhibitor of epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is polycystin-2 (PC2; TRPP2) channel blocker. |
| M58140 | HwTx-IV | Huwentoxin-IV (HwTx-IV) is a 35-residue neurotoxin peptide with potential application as a novel analgesic. Huwentoxin-IV, a component of tarantula venom, potently blocks sodium channels and is an attractive scaffold for engineering a Nav1.7-selective molecule. |
| M42248 | ProTx II TFA | ProTx II TFA is a selective blocker of Nav1.7 sodium channels with an IC50 of 0.3 nM, and is at least 100-fold selective for Nav1.7 over other sodium channel subtypes. |
| M5069 | S0859 | S0859 is an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). |
| M5897 | Prilocaine | Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. |
| M56574 | A-317567 | A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM. |
| M56573 | XPC-6444 | XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). |
| M56572 | TC-N 1752 | TC-N 1752 is a potent and orally active inhibitor of Nav1.7, with IC50s of 0.17 μM, 0.3 μM, 0.4 μM, 1.1 μM and 2.2 μM at hNav1.7, hNav1.3, hNav1.4, hNaV1.5 and rNav1.8, respectively. |
| M56571 | Nav1.8-IN-4 | Nav1.8-IN-4 is a Nav1.8 channel inhibitor (IC50=0.014 μM). |
| M56570 | MTSEA-Fluorescein | MTSEA-Fluorescein is a fluorescent probe that can be used for ion channel research. |
| M56569 | Suzetrigine phenol | Suzetrigine phenol is the phenolate form of the sodium channel modulator Suzetrigine. |
| M56568 | KC 12291 hydrochloride | KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). |
| M56567 | NaV1.2/1.6 channel blocker-1 | NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker, with IC50s of 9.8 and 24.4 μM for rNaV1.6 and hNaV1.2, respectively. |
| M54821 | ASN008 | ASN008 is a permanently positively charged sodium channel blocker. |
| M53703 | Psalmotoxin 1 | Psalmotoxin 1 (PcTx1) is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). |
| M52723 | Jingzhaotoxin-III | Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. |
| M52722 | Huwentoxin-IV | Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. |
| M52721 | Phrixotoxin 3 | Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. |
| M52720 | APETx2 | APETx2, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC50 of 63 nM. |
| M52719 | β-Pompilidotoxin | β-Pompilidotoxin (β-PMTX), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells. |
| M52718 | µ-Conotoxin-CnIIIC | μ-Conotoxin-CnIIIC is a 22-residue conopeptide that can be isolated from Conus consors. |
| M52717 | µ-Conotoxin KIIIA | μ-Conotoxin KIIIA is an analgesic μ-conotoxin that can be isolated from Conus kinoshitai. |
| M52716 | µ-Conotoxin SIIIA | μ-Conotoxin SIIIA is a tetrodotoxin (TTX)-resistant sodium channel blocker. |
| M52715 | ω-Conotoxin CVIB | ω-Conotoxin CVIB is a non-selective N- and P/Q-type voltage-gated calcium channels (VGCCs) antagonist. |
| M52714 | μ-Conotoxin PIIIA | μ-Conotoxin PIIIA is a sodium channel (NaV 1.4) blocker. |
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