| Cat.No. | Name | Information |
|---|---|---|
| M2943 | Pifithrin-μ | Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy. |
| M2036 | Pifithrin-α | Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. |
| M2578 | RITA | RITA (NSC 652287) is a MDM2 inhibitor and DNA damage agent for A498 (wild type) and TK-10 (mutation) cell lines with a GI50 of 17 nM and 32 nM, respectively. |
| M10394 | FL118 | FL118 is an inhibitor of human survivin expression, activating tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells. |
| M11512 | CBL0137 hydrochloride | CBL0137 hydrochloride is an inhibitor of FACT, the histone molecule chaperone. FACT promotes the formation of chromatin transcription complexes. CBL0137 hydrochlorideye also activated p53 and inhibited NF-κB, with EC50 values of 0.37 and 0.47 μM, respectively. |
| M10690 | Sulanemadlin | Sulanemadlin (ALRN-6924) is a stapled peptide that blocks interactions between p53 and both MDM2 and MDMX. |
| M9623 | APR-246 (Eprenetapopt) | APR-246 (Eprenetapopt) is the first-in-class small molecule to restore wild-type p53 function in TP53 mutant cells. APR-246 (Eprenetapopt) also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of REDOX balance in cells. |
| M9387 | Spermine | Spermine is a biogenic polyamine formed from spermidine, which binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner. |
| M9302 | CBL0137 | CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM. |
| M8720 | PK11000 | PK11000 is a sulfhydryl active anticancer compound that stabilizes wild-type and mutated p53 through selective alkylation of two surface cysteines without interfering with their DNA binding. |
| M8014 | Pifithrin-β hydrobromide | Pifithrin-β hydrobromide is a stabilized pifithrin-α analog as well as a specific p53 inhibitor with low cytotoxicity. |
| M7994 | PRIMA-1 | PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. |
| M7135 | PhiKan 083 | PhiKan 083 is a carbazole derivative that stabilizes Y220C, a mutant of p53, with a Kd value of 167 μM.PhiKan 083 can be used in cancer-related research. |
| M7054 | NSC 146109 hydrochloride | NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent. NSC 146109 hydrochloride activates p53-dependent transcription. NSC 146109 hydrochloride targets MDMX and can be used for breast cancer research. |
| M6958 | MIRA-1 | MIRA-1 is a maleimide analogue. MIRA-1 can induce apoptosis in mutant p53 cells via restoration of p53-dependent transcriptional transactivation. |
| M5192 | NSC59984 | NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation. |
| M5004 | Kevetrin hydrochloride | Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. |
| M4558 | Ziyuglycoside-I | Ziyuglycoside I, isolated from S. officinalis root, has anti-wrinkle activity and increases type I collagen expression. Ziyuglycoside I can be used as an active ingredient in cosmetics. Ziyuglycoside I can induce p53-mediated cell cycle arrest and apoptosis, which can be used in the study of triple negative breast cancer. |
| M4302 | Solasodine | Solasodine (Purapuridine) is a steroid alkaloid found in solanaceae plants. Solasodine has neuroprotective, antifungal, antihypertensive, anticancer, antiatherosclerotic, antiandrogen and anti-inflammatory activities. |
| M3660 | Amifostine | Amifostine is a phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. |
| M3159 | Tenovin-3 | Tenovin-3 increases p53 levels. Tenovin-3 increase K40 Ac-tubulin levels. |
| M2598 | Inauhzin | Inauhzin is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell). |
| M2570 | Tenovin-6 | Tenovin-6 is a small molecule activator of p53 transcriptional activity. |
| M2068 | JNJ-26854165 | JNJ-26854165 (Serdemetan) is a novel activator of p53 capable of inducing apoptosis in cancer cell lines. |
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