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FL118

Cat. No. M10394

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FL118 Structure
Synonym:

FL-118; CAS# 151636-76-9

Size Price Availability Quantity
1mg USD 90  USD90 In stock
2mg USD 140  USD140 In stock
5mg USD 200  USD200 In stock
10mg USD 260  USD260 In stock
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Biological Activity

FL118 is a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance. FL118 inhibits human survivinion expression and activates tumor suppressor p53 as a MOA in p53 wild-type cancer cells.

FL118 (10 and 100 nM; 48 h) inhibits PI3K/AKT/mTOR signaling pathway, and affects the expression level of vimentin and E-cadherin in ovarian cancer cells. FL118 (0-500 nM; 24, 48, 72 h) regulates survivin, McL-1, XIAP, cIAP2, c-MYc and mKras by regulating DDX5. FL118 (0-1 μM, 24 h) shows significant cytotoxic activity against the three tumor cell lines (A549, MDA-MB-231, and RM-1 cells).

Product Citations
Chemical Information
Molecular Weight 392.36
Formula C21H16N2O6
CAS Number 135415-73-5
Solubility (25°C) DMSO 1 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Rabi Thangaiyan, et al. Am J Transl Res. Kras mutation subtypes distinctly affect colorectal cancer cell sensitivity to FL118, a novel inhibitor of survivin, Mcl-1, XIAP, cIAP2 and MdmX

[2] Zhenxue Tang, et al. Life Sci. Pyroptosis is involved in the inhibitory effect of FL118 on growth and metastasis in colorectal cancer

[3] Qi Weng, et al. Cancer Chemother Pharmacol. In vitro evaluation of FL118 and 9-Q20 cytotoxicity and cellular uptake in 2D and 3D different cell models

[4] Xiang Ling, et al. J Exp Clin Cancer Res. An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer

[5] Zhihong Yang, et al. Biosci Trends. FL118, a novel camptothecin analogue, suppressed migration and invasion of human breast cancer cells by inhibiting epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway

[6] Jin Wang, et al. Am J Transl Res. FL118, a novel survivin inhibitor, wins the battle against drug-resistant and metastatic lung cancers through inhibition of cancer stem cell-like properties

[7] David Westover, et al. Mol Cancer. FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance

[8] Xiang Ling, et al. Cancer Res. FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX

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Keywords: FL118, FL-118; CAS# 151636-76-9 supplier, p53, inhibitors, activators

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