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Cat. No. M10394
FL118 Structure

FL-118; CAS# 151636-76-9

Size Price Availability Quantity
10mg USD 630  USD700 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

FL118 is a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance. FL118 inhibits human survivinion expression and activates tumor suppressor p53 as a MOA in p53 wild-type cancer cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 392.36
Formula C21H16N2O6
CAS Number 135415-73-5
Purity >98%
Storage at -20°C

Kras mutation subtypes distinctly affect colorectal cancer cell sensitivity to FL118, a novel inhibitor of survivin, Mcl-1, XIAP, cIAP2 and MdmX
Rabi Thangaiyan, et al. Am J Transl Res. 2021 Jul 15;13(7):7458-7474. PMID: 34377229.

Pyroptosis is involved in the inhibitory effect of FL118 on growth and metastasis in colorectal cancer
Zhenxue Tang, et al. Life Sci. 2020 Sep 15;257:118065. PMID: 32659366.

In vitro evaluation of FL118 and 9-Q20 cytotoxicity and cellular uptake in 2D and 3D different cell models
Qi Weng, et al. Cancer Chemother Pharmacol. 2019 Sep;84(3):527-537. PMID: 31030236.

An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer
Xiang Ling, et al. J Exp Clin Cancer Res. 2018 Oct 3;37(1):240. PMID: 30285798.

FL118, a novel camptothecin analogue, suppressed migration and invasion of human breast cancer cells by inhibiting epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway
Zhihong Yang, et al. Biosci Trends. 2018;12(1):40-46. PMID: 29553100.

FL118, a novel survivin inhibitor, wins the battle against drug-resistant and metastatic lung cancers through inhibition of cancer stem cell-like properties
Jin Wang, et al. Am J Transl Res. 2017 Aug 15;9(8):3676-3686. PMID: 28861158.

FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance
David Westover, et al. Mol Cancer. 2015 Apr 28;14:92. PMID: 25928015.

FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX
Xiang Ling, et al. Cancer Res. 2014 Dec 15;74(24):7487-97. PMID: 25512388.

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Keywords: FL118, FL-118; CAS# 151636-76-9 supplier, p53, inhibitors

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