Cat.No. | Name | Information |
---|---|---|
M2943 | Pifithrin-μ | Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy. |
M2578 | RITA | RITA (NSC 652287) is a MDM2 inhibitor and DNA damage agent for A498 (wild type) and TK-10 (mutation) cell lines with a GI50 of 17 nM and 32 nM, respectively. |
M2036 | Pifithrin-α | Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. |
M40975 | PK11007 | PK11007 is a mild thiol alkylating agent with anticancer activity that stabilizes p53 through selective alkylation of two surface-exposed cysteines without affecting its DNA-binding activity. It also induces death of mutant p53 cancer cells by increasing reactive oxygen species (ROS) levels. |
M27719 | PhiKan 083 hydrochloride | PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM[1], and a relative binding affinity (Kd) of 150 μM in Ln229 cells. |
M25519 | MS7972 | MS7972 is a small molecule that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM. |
M21694 | 2-Vinyl-4-quinazolinol (STIMA-1) | 2-Vinyl-4-quinazolinol (STIMA-1) is a bioactive compound. STIMA-1 can restore the activity of p63. STIMA-1 can activate the proliferation and differentiation of keratinocytes. |
M21693 | ReACp53 | ReACp53 is a cell-penetrating peptide inhibitor of p53 aggregation, inhibits p53 amyloid formation, rescues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC). |
M21692 | CP-31398 dihydrochloride | CP-31398 dihydrochloride is a novel p53-stabilizing agent, stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. |
M21478 | ELX-02 disulfate | ELX-02 disulfate (NB-124 disulfate) is a first-in-class synthetic eukaryotic ribosomal specific glycoside (ERSG) that can be used to study genetic diseases caused by nonsense mutations. |
M21476 | ELX-02 sulfate | ELX-02 sulfate (NB-124 sulfate) is a first-in-class synthetic eukaryotic ribosome-specific glycoside (ERSG) that can be used to study genetic diseases caused by nonsense mutations. |
M13551 | COTI-2 | COTI-2, an anti-cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms. |
M11512 | CBL0137 hydrochloride | CBL0137 hydrochloride is an inhibitor of FACT, the histone molecule chaperone. FACT promotes the formation of chromatin transcription complexes. CBL0137 hydrochlorideye also activated p53 and inhibited NF-κB, with EC50 values of 0.37 and 0.47 μM, respectively. |
M10690 | Sulanemadlin (ALRN6924) | ALRN-6924 is a stapled peptide that blocks interactions between p53 and both MDM2 and MDMX. |
M10394 | FL118 | FL118 is an inhibitor of human survivin expression, activating tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells. |
M9623 | APR-246 (Eprenetapopt) | APR-246 (Eprenetapopt) is the first-in-class small molecule to restore wild-type p53 function in TP53 mutant cells. APR-246 (Eprenetapopt) also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of REDOX balance in cells. |
M9387 | Spermine | Spermine is a biogenic polyamine formed from spermidine, which binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner. |
M9302 | CBL0137 | CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM. |
M8720 | PK11000 | PK11000 is a sulfhydryl active anticancer compound that stabilizes wild-type and mutated p53 through selective alkylation of two surface cysteines without interfering with their DNA binding. |
M8014 | Cyclic Pifithrin-α hydrobromide | Cyclic Pifithrin-α hydrobromide is a stabilized pifithrin-α analog as well as a specific p53 inhibitor with low cytotoxicity. |
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