| Cat.No. | Name | Information |
|---|---|---|
| M10394 | FL118 | FL118 is an inhibitor of human survivin expression, activating tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells. |
| M2943 | Pifithrin-μ | Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy. |
| M2578 | RITA | RITA (NSC 652287) is a MDM2 inhibitor and DNA damage agent for A498 (wild type) and TK-10 (mutation) cell lines with a GI50 of 17 nM and 32 nM, respectively. |
| M2036 | Pifithrin-α | Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. |
| M58435 | Pifithrin-α, p-Nitro, Cyclic | Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue. |
| M55034 | SCH529074 | SCH529074 is an orally active, potent activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53. |
| M43013 | Rezatapopt | Rezatapopt is a first-in-class p53 reactivator that selectively binds to the mutated p53 Y220C protein and restores wild-type activity, used to inhibit solid tumor with p53 mutation. |
| M40975 | PK11007 | PK11007 is a mild thiol alkylating agent with anticancer activity that stabilizes p53 through selective alkylation of two surface-exposed cysteines without affecting its DNA-binding activity. It also induces death of mutant p53 cancer cells by increasing reactive oxygen species (ROS) levels. |
| M29665 | C16-Ceramide | C16-Ceramide is a natural small molecule activating p53 through the direct and selective binding. |
| M28765 | SLMP53-1 | SLMP53-1 is a wild-type and mutant p53 reactivator with promising antitumor activity. SLMP53-1 mediates the reprograming of glucose metabolism in cancer cells. SLMP53-1 depletes angiogenesis, decreasing endothelial cell tube formation and vascular endothelial growth factor (VEGF) expression levels. |
| M28049 | SP-141 | SP-141 is a specific inhibitor of MDM2. SP-141 promotes MDM2 auto-ubiquitination and degradation. SP-141 might be used for the research of pancreatic cancer and breast cancer cells. |
| M27719 | PhiKan 083 hydrochloride | PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM[1], and a relative binding affinity (Kd) of 150 μM in Ln229 cells. |
| M25519 | MS7972 | MS7972 is a small molecule that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM. |
| M21694 | 2-Vinyl-4-quinazolinol (STIMA-1) | 2-Vinyl-4-quinazolinol (STIMA-1) is a bioactive compound. STIMA-1 can restore the activity of p63. STIMA-1 can activate the proliferation and differentiation of keratinocytes. |
| M21693 | ReACp53 | ReACp53 is a cell-penetrating peptide inhibitor of p53 aggregation, inhibits p53 amyloid formation, rescues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC). |
| M21692 | CP-31398 dihydrochloride | CP-31398 dihydrochloride is a novel p53-stabilizing agent, stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. |
| M21478 | ELX-02 disulfate | ELX-02 disulfate (NB-124 disulfate) is a first-in-class synthetic eukaryotic ribosomal specific glycoside (ERSG) that can be used to study genetic diseases caused by nonsense mutations. |
| M21476 | ELX-02 sulfate | ELX-02 sulfate (NB-124 sulfate) is a first-in-class synthetic eukaryotic ribosome-specific glycoside (ERSG) that can be used to study genetic diseases caused by nonsense mutations. |
| M13551 | COTI-2 | COTI-2, an anti-cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms. |
| M13550 | Amifostine thiol | Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine . Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway. |
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