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p53 Tumor protein p53

Cat.No.  Name Information
M2943 Pifithrin-μ Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
M2578 RITA RITA (NSC 652287) is a MDM2 inhibitor and DNA damage agent for A498 (wild type) and TK-10 (mutation) cell lines with a GI50 of 17 nM and 32 nM, respectively.
M2036 Pifithrin-α Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.
M40975 PK11007 PK11007 is a mild thiol alkylating agent with anticancer activity that stabilizes p53 through selective alkylation of two surface-exposed cysteines without affecting its DNA-binding activity. It also induces death of mutant p53 cancer cells by increasing reactive oxygen species (ROS) levels.
M27719 PhiKan 083 hydrochloride  PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM[1], and a relative binding affinity (Kd) of 150 μM in Ln229 cells.
M25519 MS7972 MS7972 is a small molecule that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM.
M21694 2-Vinyl-4-quinazolinol (STIMA-1) 2-Vinyl-4-quinazolinol (STIMA-1) is a bioactive compound. STIMA-1 can restore the activity of p63. STIMA-1 can activate the proliferation and differentiation of keratinocytes.
M21693 ReACp53 ReACp53 is a cell-penetrating peptide inhibitor of p53 aggregation, inhibits p53 amyloid formation, rescues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).
M21692 CP-31398 dihydrochloride CP-31398 dihydrochloride is a novel p53-stabilizing agent, stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
M21478 ELX-02 disulfate ELX-02 disulfate (NB-124 disulfate) is a first-in-class synthetic eukaryotic ribosomal specific glycoside (ERSG) that can be used to study genetic diseases caused by nonsense mutations.
M21476 ELX-02 sulfate ELX-02 sulfate (NB-124 sulfate) is a first-in-class synthetic eukaryotic ribosome-specific glycoside (ERSG) that can be used to study genetic diseases caused by nonsense mutations.
M13551 COTI-2 COTI-2, an anti-cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms.
M11512 CBL0137 hydrochloride CBL0137 hydrochloride is an inhibitor of FACT, the histone molecule chaperone. FACT promotes the formation of chromatin transcription complexes. CBL0137 hydrochlorideye also activated p53 and inhibited NF-κB, with EC50 values of 0.37 and 0.47 μM, respectively.
M10690 Sulanemadlin (ALRN6924) ALRN-6924 is a stapled peptide that blocks interactions between p53 and both MDM2 and MDMX.
M10394 FL118 FL118 is an inhibitor of human survivin expression, activating tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells.
M9623 APR-246 (Eprenetapopt) APR-246 (Eprenetapopt) is the first-in-class small molecule to restore wild-type p53 function in TP53 mutant cells. APR-246 (Eprenetapopt) also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of REDOX balance in cells.
M9387 Spermine Spermine is a biogenic polyamine formed from spermidine, which binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner.
M9302 CBL0137 CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM.
M8720 PK11000 PK11000 is a sulfhydryl active anticancer compound that stabilizes wild-type and mutated p53 through selective alkylation of two surface cysteines without interfering with their DNA binding.
M8014 Cyclic Pifithrin-α hydrobromide Cyclic Pifithrin-α hydrobromide is a stabilized pifithrin-α analog as well as a specific p53 inhibitor with low cytotoxicity.




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