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CP-31398 dihydrochloride is a novel p53-stabilizing agent, stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. CP-31398 (36.75 μM, 16 h) induces p21 in p53-mutant cells. CP-31398 (15 μg/mL, 20 hours) could induce apoptosis and cell cycle arrest in SW480 cells.
In vivo, CP-31398 (100 mg/kg, orally) exhibits significant anti-tumor activity in mice models.
| Molecular Weight | 435.39 |
| Formula | C22H28Cl2N4O |
| CAS Number | 1217195-61-3 |
| Solubility (25°C) | Water ≥ 90 mg/mL DMSO 5 mg/mL (ultrasonic and warming) |
| Storage | 4°C, protect from light, dry, sealed |
| Related p53 Products |
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Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue. |
| PK095
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| HLI373
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| Cjoc42
Cjoc42 is a compound capable of binding to gankyrin. |
| MDM2-IN-1
MDM2-IN-1 is a synthetic MDM2-p53 interaction (MDM2) inhibitor and contains the trans (D-)configuration. |
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