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Tenovin-1

Cat. No. M2027
Tenovin-1 Structure
Size Price Availability Quantity
50mg USD 198  USD220 In stock
100mg USD 315  USD350 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tenovin-1 is a p53 activator and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 induces expression from an endogenous p53-dependent promoter. Tenovin-1 exhibits potent antiproliferative activity in vitro. Tenovin-1 (10μM) elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells. Tenovin-1 has been shown to activate and elevate acetylated p53 levels, induce apoptosis in vitro, and acetylate histone H4. While tenovin-1 demonstrates low genotoxicity, the compound has poor water solubility, which limits its uses in vivo.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 369.48
Formula C20H23N3O2S
CAS Number 380315-80-0
Purity >98%
Solubility DMSO
Storage at -20°C
References

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.
Lain S, et al. Cancer Cell. 2008 May;13(5):454-63. PMID: 18455128.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tenovin-1 supplier, p53, inhibitors

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