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Inauhzin

Cat. No. M2598
Inauhzin Structure
Synonym:

INZ

Size Price Availability Quantity
10mM*1mL in DMSO USD 108  USD108 In stock
5mg USD 100  USD100 In stock
10mg USD 128  USD128 In stock
50mg USD 480  USD480 In stock
100mg USD 700  USD700 In stock
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Quality Control & Documentation
Biological Activity

Inauhzin is a novel small molecule that reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell) effectively By increasing p53 acetylation and preventing MDM2-mediated ubiquitylation of p53 in cells, INZ stabilizes p53,though not directly in vitro. Remarkably, INZ inhibits cell proliferation, induces senescence and tumour-specific apoptosis.

Chemical Information
Molecular Weight 469.58
Formula C25H19N5OS2
CAS Number 309271-94-1
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhang Q,et al. EMBO Mol Med. A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53.

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Keywords: Inauhzin, INZ supplier, p53, inhibitors, activators


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