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Inauhzin

Cat. No. M2598

All AbMole products are for research use only, cannot be used for human consumption.

Inauhzin Structure
Synonym:

INZ

Size Price Availability Quantity
10mM*1mL in DMSO USD 65  USD65 In stock
5mg USD 60  USD60 In stock
10mg USD 90  USD90 In stock
50mg USD 270  USD270 In stock
100mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

Inauhzin is a novel small molecule that reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell) effectively By increasing p53 acetylation and preventing MDM2-mediated ubiquitylation of p53 in cells, INZ stabilizes p53,though not directly in vitro. Remarkably, INZ inhibits cell proliferation, induces senescence and tumour-specific apoptosis.

Chemical Information
Molecular Weight 469.58
Formula C25H19N5OS2
CAS Number 309271-94-1
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Zhang Q,et al. EMBO Mol Med. A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53.

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Keywords: Inauhzin, INZ supplier, p53, inhibitors, activators

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