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Inauhzin

Cat. No. M2598
Inauhzin Structure
Synonym:

INZ

Size Price Availability Quantity
10mM*1mL in DMSO USD 103.5  USD115 In stock
5mg USD 90  USD100 In stock
10mg USD 121.5  USD135 In stock
50mg USD 432  USD480 In stock
100mg USD 630  USD700 In stock
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Quality Control
Biological Activity

Inauhzin is a novel small molecule that reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell) effectively By increasing p53 acetylation and preventing MDM2-mediated ubiquitylation of p53 in cells, INZ stabilizes p53,though not directly in vitro. Remarkably, INZ inhibits cell proliferation, induces senescence and tumour-specific apoptosis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 469.58
Formula C25H19N5OS2
CAS Number 309271-94-1
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
References

A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53.
Zhang Q,et al. EMBO Mol Med. 2012 Apr;4(4):298-312. PMID: 22331558.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Inauhzin, INZ supplier, p53, inhibitors

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