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PhiKan 083 hydrochloride

Cat. No. M7135
PhiKan 083 hydrochloride Structure


Size Price Availability
1mg USD 112.5  USD125 4-7 Days
5mg USD 135  USD150 4-7 Days
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

PhiKan 083 is a p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 274.79
Formula C16H18N2.HCl
CAS Number 880813-36-5
Purity >99%
Solubility Water 2 mg/mL
Storage at -20°C

A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells
Ramasamy Paulmurugan, et al. Oncotarget. 2018 Apr 20;9(30):21495-21511. PMID: 29765555.

Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer.
Cheng, et al. J Pharmacol Exp Ther. 2014;351: 559. PMID: 25277138.

Effect of Y220C mutation on p53 and its rescue mechanism: a computer chemistry approach
Shah Md Abdur Rauf, et al. Protein J. 2013 Jan;32(1):68-74. PMID: 23315175.

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
Frank M Boeckler, et al. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5. PMID: 18650397.

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Keywords: PhiKan 083 hydrochloride, PhiKan-083 supplier, p53, inhibitors

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