| Cat.No. | Name | Information |
|---|---|---|
| M2943 | Pifithrin-μ | Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy. |
| M2036 | Pifithrin-α | Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. |
| M2578 | RITA | RITA (NSC 652287) is a MDM2 inhibitor and DNA damage agent for A498 (wild type) and TK-10 (mutation) cell lines with a GI50 of 17 nM and 32 nM, respectively. |
| M10394 | FL118 | FL118 is an inhibitor of human survivin expression, activating tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells. |
| M9623 | Eprenetapopt | Eprenetapopt (APR-246) is the first-in-class small molecule to restore wild-type p53 function in TP53 mutant cells. APR-246 (Eprenetapopt) also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of REDOX balance in cells. |
| M28375 | RO-5963 | RO-5963 is a dual p53-MDM2 and p53-MDMX inhibitor with IC50s of ~17 nM and ~24 nM, respectively. |
| M28358 | MI-1061 TFA | MI-1061 TFA is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 TFA potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity. |
| M28357 | MI-1061 | MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity. |
| M28282 | Exaluren | Exaluren (ELX-02) is an synthetic eukaryotic ribosome-selective glycoside that induces read through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren is used for the research of cystic fibrosis caused by nonsense mutations. |
| M20697 | Triglycidyl Isocyanurate (Teroxirone) | Triglycidyl Isocyanurate, also known as Teroxirone, is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry. |
| M19138 | Sanggenol L | Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells. Sanggenol L induces of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of p53 in p |
| M13552 | CTX1 | CTX1 is a p53 activator that overcomes HdmX-mediated p53 repression. CTX1 exhibits potent anti-cancer activity in a mouse acute myeloid leukemia (AML) model system. |
| M11440 | PC14586 | PC14586 is the first-in-class oral small molecule p53 Y220C activator to enter the clinical phase, which induces the transformation of p53 protein from mutant to wild-type conformation in a dose-dependent manner. |
| M8656 | DPBQ | DPBQ is a potent apoptosis inducer that is specific for high-ploidy cells. |
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