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MI-1061 

Cat. No. M28357

All AbMole products are for research use only, cannot be used for human consumption.

MI-1061  Structure

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Quality Control & Documentation
Biological Activity

MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity.

Chemical Information
Molecular Weight 582.45
Formula C30H26Cl2FN3O4
CAS Number 1410737-34-6
Form Solid
Solubility (25°C) DMSO 160 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ryan P Wurz, et al. J Med Chem. Targeted Degradation of MDM2 as a New Approach to Improve the Efficacy of MDM2-p53 Inhibitors

[2] Yangbing Li, et al. J Med Chem. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression

[3] Angelo Aguilar, et al. J Med Chem. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles

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  Catalog
Abmole Inhibitor Catalog




Keywords: MI-1061  supplier, p53, inhibitors, activators

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