| Cat.No. | Name | Information |
|---|---|---|
| M2943 | Pifithrin-μ | Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy. |
| M2036 | Pifithrin-α | Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. |
| M2578 | RITA | RITA (NSC 652287) is a MDM2 inhibitor and DNA damage agent for A498 (wild type) and TK-10 (mutation) cell lines with a GI50 of 17 nM and 32 nM, respectively. |
| M10394 | FL118 | FL118 is an inhibitor of human survivin expression, activating tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells. |
| M2027 | Tenovin-1 | Tenovin-1 is a small molecule activator of p53 transcriptional activity. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase (DHODH) inhibitor. |
| M55901 | PK095 | PK095 is a p53 mutant stabilizer. |
| M55900 | HLI373 | HLI373 is an efficacious Hdm2 inhibitor. |
| M55899 | Cjoc42 | Cjoc42 is a compound capable of binding to gankyrin. |
| M55898 | MDM2-IN-1 | MDM2-IN-1 is a synthetic MDM2-p53 interaction (MDM2) inhibitor and contains the trans (D-)configuration. |
| M55897 | p53-MDM2-IN-4 | p53-MDM2-IN-4 is an inhibitor of p53-MDM2/X protein interaction, with a Ki value of 3.079 μM. |
| M55896 | HLI373 dihydrochloride | HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. |
| M54714 | BAY 1892005 | BAY 1892005, a p53 protein modulator, is active on p53 condensates and does not lead to mutant p53 reactivation. |
| M53933 | FOXO4-DRI | FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. |
| M53371 | p53 (17-26) | p53 (17-26) is amino acids 17 to 26 fragment of p53. |
| M53370 | Azurin p28 peptide | Azurin p28 peptide is a tumor-penetrated antitumor peptide. |
| M43946 | INV-102 | INV-102 is a p53 and Pax6 activator that can be used in studies related to dry eye. |
| M41719 | MS78 | MS78 is an acetylation targeting chimera (AceTAC) that acetylates the p53 tumor suppressor protein. |
| M41357 | SLMP53-2 | SLMP53-2 is a mutant p53 reactivator. |
| M41353 | p53 CBS | p53 CBS (p53 Consensus binding sequence) is a biological active peptide. |
| M31002 | ADH-6 TFA | ADH-6 TFA is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 TFA targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 TFA has the potential for the research of cancer diseases. |
| M30033 | p-nitro-Pifithrin-α | p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet . non-alcoholic fatty liver disease. |
| M29381 | ADH-6 | ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases. |
| M28916 | BI-0252 | BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis. |
| M28415 | AM-8735 | AM-8735 is a potent and selective MDM2 inhibitor with an IC50 of 25 nM. |
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