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BI-0252 

Cat. No. M28916

All AbMole products are for research use only, cannot be used for human consumption.

BI-0252  Structure

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Quality Control & Documentation
Biological Activity

BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis.

Chemical Information
Molecular Weight 566.45
Formula C30H26Cl2FN3O3
CAS Number 1818291-27-8
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Mohammad Shahidul Islam, et al. Sci Rep. Optimized spirooxindole-pyrazole hybrids targeting the p53-MDM2 interplay induce apoptosis and synergize with doxorubicin in A549 cells

[2] Andreas Gollner, et al. ChemMedChem. Targeted Synthesis of Complex Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2-p53 Inhibitors

[3] Andreas Gollner, et al. J Med Chem. Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction

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  Catalog
Abmole Inhibitor Catalog




Keywords: BI-0252  supplier, p53, inhibitors, activators

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