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ADH-6 

Cat. No. M29381

All AbMole products are for research use only, cannot be used for human consumption.

ADH-6  Structure

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Quality Control & Documentation
Biological Activity

ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases.

Chemical Information
Molecular Weight 640.64
Formula C29H36N8O9
CAS Number 2227429-65-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] L Palanikumar, et al. Nat Commun. Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

[2] Michael Zaleski, et al. Ann Diagn Pathol. Should we excise? Are there any clinical or histologic features that predict upgrade in papillomas, incidental or non-incidental?

[3] Erna Guo, et al. Oncol Lett. Prognostic value of alcohol dehydrogenase mRNA expression in gastric cancer

[4] Shalini Arora, et al. Ann Surg Oncol. Atypical ductal hyperplasia at margin of breast biopsy--is re-excision indicated?

[5] T Matsushima. Nihon Rinsho. [ADH isoenzymes]

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  Catalog
Abmole Inhibitor Catalog




Keywords: ADH-6  supplier, p53, inhibitors, activators

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