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Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine . Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway.
| Molecular Weight | 134.24 |
| CAS Number | 31098-42-7 |
| Solubility (25°C) | DMSO 150 mg/mL Water 90 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
[3] Michael I Koukourakis. Semin Oncol. Amifostine: is there evidence of tumor protection?
[5] L M Shaw, et al. Semin Oncol. Pharmacokinetic profile of amifostine
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Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue. |
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