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PK11000 is a sulfhydryl active anticancer compound that stabilizes wild-type and mutated p53 through selective alkylation of two surface cysteines without interfering with their DNA binding. In addition, PK11007 is independent of p53 and disrupts reactive oxygen species (ROS) detoxification in many mutated P53 cancer cells. PK11007 has shown anticancer activity in many cancer cell lines while pushing low cytotoxicity into normal cells.
| Molecular Weight | 236.63 |
| Formula | C6H5ClN2O4S |
| CAS Number | 38275-34-2 |
| Form | Solid |
| Solubility (25°C) | Water: 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Michael J Duffy, et al. Mutant p53 as a target for cancer treatment
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Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue. |
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