| Cat.No. | Name | Information |
|---|---|---|
| M4808 | TRV130 hydrochloride | TRV130 (Oliceridine) hydrochloride is a novel μ-opioid receptor (MOR) G protein-biased ligand. |
| M1579 | Naloxone | Naloxone is an opioid inverse agonist drug used to counter the effects of opiate overdose. |
| M9615 | DAMGO | DAMGO is an opioid receptor agonist with the ability to affect the locomotive activity in rodents, Kd value is 3.46 nM for native μ-OPR. |
| M29719 | Anrikefon acetate | Anrikefon (HSK21542) acetate is a kappa opioid receptor agonist with analgesic effect. |
| M29470 | Anrikefon | Anrikefon (HSK21542) is a kappa opioid receptor agonist with analgesic effect. |
| M29333 | (±)-J-113397 | (±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist with a Ki of 1.8 nM for cloned human ORL1. J-113397 inhibited nociceptin/orphanin FQ-stimulated GTPγS binding to CHO cells expressing ORL1 with an IC50 value of 5.3 nM. J-113397 can be used for researching the physiological roles of nociceptin/orphanin FQ. |
| M29229 | AT-121 | AT-121 is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects. |
| M28848 | BMS-986188 | BMS-986188 is a selective positive allosteric modulator of δ-opioid receptor with an EC50 of 0.05 μM. |
| M28824 | Nociceptin | Nociceptin, a heptadecapeptide, is the endogenous ligand of the nociceptin receptor, acting as a potent anti-analgesic. |
| M28209 | LY2444296 | LY2444296 is an orally bioavailable, high-affinity and selective short-acting kappa opioid receptor (KOPR) antagonist, with a Ki value of ∼1 nM. LY2444296 exhibits anti-anxiety like effects. |
| M28208 | Naldemedine tosylate | Naldemedine (S-297995) tosylate is an orally active μ-opioid receptor antagonist (PAMORA). Naldemedine tosylate shows potent binding affinities (Ki=0.34, 0.43, 0.94 nM, respectively) and antagonist activities (IC50=25.57, 7.09, 16.1 nM, respectively) for recombinant human μ-, δ-, and κ- opioid receptors. Naldemedine can be used in opioid-induced constipation (OIC) research. |
| M28180 | (+)-N-Allylnormetazocine hydrochloride | (+)-N-Allylnormetazocine ((+)-SKF 10047) hydrochloride is a benzomorphan opioid with psychotomi metic effects. (+)-N-Allylnormetazocine hydrochloride is an opioid receptor antagonist with Ki values of 300 nM and 27 μM for σ1 and σ2 opioid receptors, respectively. (+)-N-Allylnormetazocine hydrochloride can be used for the research of neurological disease. |
| M28066 | KNT-127 | KNT-127 is a potent and selective δ-opioid receptor agonist effective by systemic administration. KNT-127 shows selectivity for the δ-receptor (Ki 0f 21.3, 0.16, 153 nM for opioid μ-, δ-, and κ-receptors, respectively). KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens and median pre-frontal cortex. |
| M28028 | Enadoline hydrochloride | Enadoline (CI-977) hydrochloride is a highly selective, brain-penetrating, and nonpeptide kappa-opioid receptor (KOR) agonist (Ki=1.25 nM). Antinociceptive effects. |
| M28027 | Enadoline | Enadoline (CI-977) is a highly selective, brain-penetrating, and nonpeptide kappa-opioid receptor (KOR) agonist (Ki=1.25 nM). Antinociceptive effects. |
| M27965 | TAN-67 dihydrobromide | TAN-67 (SB-205607) dihydrobromide is a potent and selective nonpeptidic δ-opioid receptor agonist with a Ki value of 0.647 nM. TAN-67 dihydrobromide has neuroprotective effect. TAN-67 dihydrobromide can be used in research of ischemic stroke. |
| M27962 | MT-7716 hydrochloride | MT-7716 hydrochloride (W-212393 hydrochloride) is a selective non-peptide nociceptin receptor (NOP) agonist and promising potential treatment drug for alcohol abuse and relapse prevention. |
| M27855 | ICI 199441 | ICI 199441 is a potent and selective κ-opioid receptor agonist. ICI 199441 can improve heart resistance to ischemia/reperfusion. |
| M21657 | Bevenopran | Bevenopran (CB-5945) is a peripheral μ-opioid receptor antagonist. |
| M21375 | BMS-986187 | BMS-986187 is a δ-opioid receptor selective orthosteric modulator (PAM) with an EC50 of 0.03 μM and a pKB of 6.02 (~1 μM). bms-986187 has no observable PAM activity at the μ receptor (EC50=3 μM). |
| M21363 | TRV-130 | TRV 130 is a novel μ-opioid receptor (MOR) G protein-biased ligand; elicits robust G protein signaling(pEC50=8.1), with potency and efficacy similar to morphine, but with far less β-arrestin recruitment and receptor internalization. |
| M21317 | EST73502 | EST73502 is a selective, orally active, μ-opioid receptor (μ-opioid receptor/MOR) agonist and σ1 receptor (σ1R) antagonist that crosses the blood-brain barrier with Ki values of 64 nM and 118 nM for MOR and σ1R effects, respectively. EST73502 can be used in pain relief studies. |
| M20425 | (-)-Menthol | (-)-Menthol is a levo isomer of menthol and used as a cooling agent that strongly activates TRPM8. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
