Free shipping on all orders over $ 500

KNT-127 

Cat. No. M28066

All AbMole products are for research use only, cannot be used for human consumption.

KNT-127  Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

KNT-127 is a potent and selective δ-opioid receptor agonist effective by systemic administration. KNT-127 shows selectivity for the δ-receptor (Ki 0f 21.3, 0.16, 153 nM for opioid μ-, δ-, and κ-receptors, respectively). KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens and median pre-frontal cortex.

Chemical Information
Molecular Weight 372.46
Formula C24H24N2O2
CAS Number 1256921-89-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Toshinori Yoshioka, et al. Neuropharmacology. KNT-127, a selective delta opioid receptor agonist, shows beneficial effects in the hippocampal dentate gyrus of a chronic vicarious social defeat stress mouse model

[2] Ayako Kawaminami, et al. Front Behav Neurosci. Selective δ-Opioid Receptor Agonist, KNT-127, Facilitates Contextual Fear Extinction via Infralimbic Cortex and Amygdala in Mice

[3] Zachariah Bertels, et al. Headache. A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia

[4] Akiyoshi Saitoh, et al. Behav Brain Res. The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice

[5] Shunsuke Tanahashi, et al. Neuropharmacology. Novel δ1-receptor agonist KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens and median pre-frontal cortex

Related Opioid Receptor Products
SNC162 

SNC162 is a delta-opioid receptor agonist with an IC50 of 0.94 nM.
ML 190 

ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC50 of 120 nM and an EC50 of 129 nM, respectively.
CCG258747 

CCG258747 is a selective GRK2 inhibitor (IC50=18 nM) with high selectivity over GRK1, GRK5, PKA, and ROCK1 (518, 83, >5500, and >550–fold, respectively).CCG258747 also blocks the internalization of the µ-opioid receptor.
Sunobinop

Sunobinop (S 117957) is a modulator of the opioid receptor-like orphan receptor (ORL1).
SCH 486757 

SCH 486757 is an orally effective pain peptide receptor (NOP) agonist.
  Catalog
Abmole Inhibitor Catalog




Keywords: KNT-127  supplier, Opioid Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.