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DAMGO

Cat. No. M9615
DAMGO Structure
Synonym:

RX783006; Dagol

Size Price Availability Quantity
10mg USD 165  USD165 In stock
25mg USD 360  USD360 In stock
50mg USD 600  USD600 In stock
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Quality Control
Biological Activity

DAMGO is an opioid receptor agonist with the ability to affect the locomotive activity in rodents, Kd value is 3.46 nM for native μ-OPR. DAMGO abolishes the neuroprotective effect of CXCL12 in N-methyl-d-aspartate (NMDA) neurotoxicity studies.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 513.59
Formula C26H35N5O6
CAS Number 78123-71-4
Purity 98.69%
Solubility DMSO ≥ 21 mg/mL
Storage -20°C, protect from light, dry, sealed
References

[1] Jeegar P Patel, et al. J Neurovirol. Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO

[2] T Onogi, et al. FEBS Lett. DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops

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Keywords: DAMGO, RX783006; Dagol supplier, Opioid Receptor, inhibitors

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