| Cat.No. | Name | Information |
|---|---|---|
| M1725 | CUDC-305 | CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class. |
| M7575 | Apoptozole | Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis. |
| M9899 | Arimoclomol maleate | Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C). |
| M9273 | HSP70-IN-1 | HSP70-IN-1 is a heat shock protein (HSP) inhibitor with an IC50 of 2.3 μM inhibiting the growth of Kasumi-1 cells. |
| M1798 | NVP-HSP990 | NVP-HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively. NVP-HSP990 has potential antineoplastic activity. |
| M1741 | Ganetespib | Ganetespib (STA-9090) is a potent synthetic small molecule inhibitor of Hsp90 with potential antineoplastic activity. |
| M2320 | 17-AAG (Tanespimycin) | 17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM. |
| M10289 | Cucurbitacin D | Cucurbitacin D induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells. |
| M9846 | JG-98 | JG-98 is an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. |
| M9304 | KNK437 | KNK437 is a specific heat shock protein (HSPA1A) inhibitor. |
| M9299 | HSF1A | HSF1A is an activator of Heat shock transcription factor 1 (HSF1). |
| M7427 | TRC 051384 | TRC 051384 is a inducer of heat shock protein Hsp70. |
| M6872 | KRIBB11 | KRIBB11 is a hSF1 inhibitor. |
| M6571 | CCT 018159 | CCT 018159 is a hsp90 inhibitor. |
| M6512 | BiP inducer X | BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78. BiP inducer X (BIX) is also an effective ER (endoplasmic reticulum) stress inhibitor. |
| M5997 | Teprenone | Teprenone(Geranylgeranylacetone; GGA)is commonly utilized to protect the gastric mucosa in peptic ulcer disease; has been shown to protect the myocardium from ischemia/reperfusion by activating heat shock proteins. |
| M4618 | Eupalinolide A | Eupalinolide A, isolated from Eupatorium lindleyanum, induces the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90. |
| M3776 | CH5138303 | CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM. |
| M3683 | Retaspimycin | Retaspimycin is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). |
| M3563 | KW-2478 | KW-2478 is a nonansamycin Hsp90α inhibitor with IC50 of 3.8 nM. |
| M3561 | Geldanamycin | Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. |
| M3528 | SNX-2112 | SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG. |
| M3197 | MPC-3100 | MPC-3100 is a fully synthetic and potent Hsp90 inhibitor with IC50 of 60 nM. |
| M3117 | VER-49009 | VER-49009 is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β. |
| M3116 | VER 155008 | VER-155008 is a potent inhibitor of the HSP70 family, with IC50 of 0.5 μM and 2.6 μM for HSP70 and Grp78, respectively, exhibits >100-fold selectivity over HSP90. |
| M2885 | NMS-E973 | NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases. |
| M2777 | IPI-504 hydrochloride | IPI-504 (Retaspimycin) hydrochloride is a potent inhibitor of HSP90 with EC50 of 63 nM. |
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