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VER-155008 is a potent inhibitor of the HSP70 family, with IC50 of 0.5 μM and 2.6 μM for HSP70 and Grp78, respectively, exhibits >100-fold selectivity over HSP90.
| Cell Experiment | |
|---|---|
| Cell lines | BT474, MB-468, HCT116, and HT29 cells |
| Preparation method | Growing all cell lines in DMEM/10% FCS with GlutaMAX-I in a humidified atmosphere of 5% CO2 in air.Using the sulforhodamine B (SRB) assay to dtermine cell proliferation . |
| Concentrations | 50 μM |
| Incubation time | 72 h |
| Animal Experiment | |
|---|---|
| Animal models | HCT116 tumor bearing |
| Formulation | 10% DMSO/5% Tween 80/85% Saline (v/v/v) |
| Dosages | 40 mg/kg |
| Administration | i.v. |
| Molecular Weight | 556.4 |
| Formula | C25H23Cl2N7O4 |
| CAS Number | 1134156-31-2 |
| Solubility (25°C) | DMSO: 35 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related HSP Products |
|---|
| NCT-58
NCT-58 is a potent inhibitor of C-terminal HSP90. |
| Gedunin
Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. |
| VER-49009
VER-49009 is a Hsp90 inhibitor, with an IC50 of 25 nM and a Kd of 78 nM. |
| YUM70
YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity. YUM70 induces endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer. |
| Hsp70-derived octapeptide
Hsp70-derived octapeptide is a conserved octapeptide of the C-terminal end of Hsp70, which physically interacts with tetratricopeptide repeat (TPR) motifs. |
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