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HSP Heat shock proteins

Inhibitors

Cat.No.  Name Information
M1725 CUDC-305 CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class.
M7575 Apoptozole Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
M9899 Arimoclomol maleate Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C).
M9273 HSP70-IN-1 HSP70-IN-1 is a heat shock protein (HSP) inhibitor with an IC50 of 2.3 μM inhibiting the growth of Kasumi-1 cells.
M11446 NPX800 NPX800 is an oral HSF1 inhibitor of FIC. NPX800 has the potential to be used in cancer research.
M11166 Shepherdin (79-87) Shepherdin (79-87) is a 79 to 87 amino acid fragment of Shepherdin. Shepherdin is a peptide-mimetic antagonist of Hsp90-Survivin complex. Has antitumor activity.
M10658 Calenduloside E Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90).
M10496 HM03 HM03 is a potent and selective HSPA5 inhibitor with anticancer activity.
M10289 Cucurbitacin D Cucurbitacin D induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
M9899 Arimoclomol maleate Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C).
M9846 JG-98 JG-98 is an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction.
M9304 KNK437 KNK437 is a novel inhibitor of acquisition of thermotolerance and heat shock protein.
M9299 HSF1A HSF1A is an activator of Heat shock transcription factor 1 (HSF1).
M9273 HSP70-IN-1 HSP70-IN-1 is a heat shock protein (HSP) inhibitor with an IC50 of 2.3 μM inhibiting the growth of Kasumi-1 cells.
M7575 Apoptozole Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
M5997 Teprenone Teprenone(Geranylgeranylacetone; GGA)is commonly utilized to protect the gastric mucosa in peptic ulcer disease; has been shown to protect the myocardium from ischemia/reperfusion by activating heat shock proteins.
M4619 Eupalinolide-B Eupalinolide A, isolated from the Eupatorium Lindleyanum, activated HSF1 and induced HSP70 expression by inhibiting its interaction with HSP90.
M3884 Celastrol Celastrol is a potent antioxidant and anti-inflammatory agent, as well as a novel HSP90 inhibitor that inhibits the function of HSP90 −Cdc37.
M3776 CH5138303 CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
M3683 Retaspimycin Retaspimycin is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90).
M3563 KW-2478 KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM.
M3561 Geldanamycin Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.
M3528 SNX-2112 SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.
M3197 MPC-3100 MPC-3100 is a fully synthetic and potent Hsp90 inhibitor with IC50 of 60 nM.



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