HSP Heat shock proteins

Inhibitors

Cat.No.	Name	Information
M1725	CUDC-305	CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class.
M7575	Apoptozole	Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
M9899	Arimoclomol maleate	Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C).
M9273	HSP70-IN-1	HSP70-IN-1 is a heat shock protein (HSP) inhibitor with an IC50 of 2.3 μM inhibiting the growth of Kasumi-1 cells.
M11446	NPX800	NPX800 is an oral HSF1 inhibitor of FIC. NPX800 has the potential to be used in cancer research.
M11166	Shepherdin (79-87)	Shepherdin (79-87) is a 79 to 87 amino acid fragment of Shepherdin. Shepherdin is a peptide-mimetic antagonist of Hsp90-Survivin complex. Has antitumor activity.
M10658	Calenduloside E	Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90).
M10496	HM03	HM03 is a potent and selective HSPA5 inhibitor with anticancer activity.
M10289	Cucurbitacin D	Cucurbitacin D induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
M9899	Arimoclomol maleate	Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C).
M9846	JG-98	JG-98 is an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction.
M9304	KNK437	KNK437 is a novel inhibitor of acquisition of thermotolerance and heat shock protein.
M9299	HSF1A	HSF1A is an activator of Heat shock transcription factor 1 (HSF1).
M9273	HSP70-IN-1	HSP70-IN-1 is a heat shock protein (HSP) inhibitor with an IC50 of 2.3 μM inhibiting the growth of Kasumi-1 cells.
M7575	Apoptozole	Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
M5997	Teprenone	Teprenone(Geranylgeranylacetone; GGA)is commonly utilized to protect the gastric mucosa in peptic ulcer disease; has been shown to protect the myocardium from ischemia/reperfusion by activating heat shock proteins.
M4619	Eupalinolide-B	Eupalinolide A, isolated from the Eupatorium Lindleyanum, activated HSF1 and induced HSP70 expression by inhibiting its interaction with HSP90.
M3884	Celastrol	Celastrol is a potent antioxidant and anti-inflammatory agent, as well as a novel HSP90 inhibitor that inhibits the function of HSP90 −Cdc37.
M3776	CH5138303	CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
M3683	Retaspimycin	Retaspimycin is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90).
M3563	KW-2478	KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM.
M3561	Geldanamycin	Geldanamycin is a natural existing HSP90 inhibitor with K_d of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.
M3528	SNX-2112	SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with K_a of 30 nM and 30 nM, uniformly more potent than 17-AAG.
M3197	MPC-3100	MPC-3100 is a fully synthetic and potent Hsp90 inhibitor with IC50 of 60 nM.

Signaling Pathways

Product Type

HSP Heat shock proteins

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