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HSP Heat shock proteins

Inhibitors

Cat.No.  Name Information
M1725 CUDC-305 CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class.
M7575 Apoptozole Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
M9899 Arimoclomol maleate Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C).
M9273 HSP70-IN-1 HSP70-IN-1 is a heat shock protein (HSP) inhibitor with an IC50 of 2.3 μM inhibiting the growth of Kasumi-1 cells.
M21405 Arimoclomol Arimoclomol (BRX-220 free base) is a heat shock protein (HSP) co-inducer. arimoclomol protects motor neurons by enhancing Hsp expression, thereby directly affecting protein aggregation and removing misfolded and misassembled proteins through the ubiquitin-proteasome system.
M20805 DTHIB DTHIB (Direct Targeted HSF1 InhiBitor) is a direct and selective inhibitor of heat shock factor 1 (HSF1) with Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB exhibits potently anticancer activities.
M20676 TAS-116 TAS-116 is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 μmol/L).
M20038 WAY-270444 WAY-270444 is a Hsp90 inhibitor/ inhibits histidine kinases C. crescentus CckA
M13684 VER-50589 VER-50589 is a Hsp90 inhibitor, with an IC50 of 21 nM and a Kd of 4.5 nM.
M13683 ML346 ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC50 of 4.6 μM for Hsp70.
M13682 HSP27 inhibitor J2 HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof.
M13681 Grp94 Inhibitor-1 Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α.
M13680 Gamitrinib TPP hexafluorophosphate Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
M13679 CCT251236 CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction.
M11446 NPX800 NPX800 is an oral HSF1 inhibitor of FIC. NPX800 has the potential to be used in cancer research.
M11166 Shepherdin (79-87) Shepherdin (79-87) is a 79 to 87 amino acid fragment of Shepherdin. Shepherdin is a peptide-mimetic antagonist of Hsp90-Survivin complex. Has antitumor activity.
M10658 Calenduloside E Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90).
M10496 HM03 HM03 is a potent and selective HSPA5 inhibitor with anticancer activity.
M10289 Cucurbitacin D Cucurbitacin D induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
M9899 Arimoclomol maleate Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C).
M9846 JG-98 JG-98 is an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction.
M9304 KNK437 KNK437 is a novel inhibitor of acquisition of thermotolerance and heat shock protein.
M9299 HSF1A HSF1A is an activator of Heat shock transcription factor 1 (HSF1).
M9273 HSP70-IN-1 HSP70-IN-1 is a heat shock protein (HSP) inhibitor with an IC50 of 2.3 μM inhibiting the growth of Kasumi-1 cells.



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