Inhibitors
Cat.No. | Name | Information |
---|---|---|
M1725 | CUDC-305 | CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class. |
M7575 | Apoptozole | Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis. |
M9899 | Arimoclomol maleate | Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C). |
M9273 | HSP70-IN-1 | HSP70-IN-1 is a heat shock protein (HSP) inhibitor with an IC50 of 2.3 μM inhibiting the growth of Kasumi-1 cells. |
M11446 | NPX800 | NPX800 is an oral HSF1 inhibitor of FIC. NPX800 has the potential to be used in cancer research. |
M11166 | Shepherdin (79-87) | Shepherdin (79-87) is a 79 to 87 amino acid fragment of Shepherdin. Shepherdin is a peptide-mimetic antagonist of Hsp90-Survivin complex. Has antitumor activity. |
M10658 | Calenduloside E | Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90). |
M10496 | HM03 | HM03 is a potent and selective HSPA5 inhibitor with anticancer activity. |
M10289 | Cucurbitacin D | Cucurbitacin D induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells. |
M9899 | Arimoclomol maleate | Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C). |
M9846 | JG-98 | JG-98 is an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. |
M9304 | KNK437 | KNK437 is a novel inhibitor of acquisition of thermotolerance and heat shock protein. |
M9299 | HSF1A | HSF1A is an activator of Heat shock transcription factor 1 (HSF1). |
M9273 | HSP70-IN-1 | HSP70-IN-1 is a heat shock protein (HSP) inhibitor with an IC50 of 2.3 μM inhibiting the growth of Kasumi-1 cells. |
M7575 | Apoptozole | Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis. |
M5997 | Teprenone | Teprenone(Geranylgeranylacetone; GGA)is commonly utilized to protect the gastric mucosa in peptic ulcer disease; has been shown to protect the myocardium from ischemia/reperfusion by activating heat shock proteins. |
M4619 | Eupalinolide-B | Eupalinolide A, isolated from the Eupatorium Lindleyanum, activated HSF1 and induced HSP70 expression by inhibiting its interaction with HSP90. |
M3884 | Celastrol | Celastrol is a potent antioxidant and anti-inflammatory agent, as well as a novel HSP90 inhibitor that inhibits the function of HSP90 −Cdc37. |
M3776 | CH5138303 | CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM. |
M3683 | Retaspimycin | Retaspimycin is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). |
M3563 | KW-2478 | KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. |
M3561 | Geldanamycin | Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. |
M3528 | SNX-2112 | SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG. |
M3197 | MPC-3100 | MPC-3100 is a fully synthetic and potent Hsp90 inhibitor with IC50 of 60 nM. |
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