Cat.No. | Name | Information |
---|---|---|
M1725 | CUDC-305 | CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class. |
M7575 | Apoptozole | Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis. |
M9899 | Arimoclomol maleate | Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C). |
M9273 | HSP70-IN-1 | HSP70-IN-1 is a heat shock protein (HSP) inhibitor with an IC50 of 2.3 μM inhibiting the growth of Kasumi-1 cells. |
M1798 | NVP-HSP990 | NVP-HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. |
M1741 | Ganetespib | Ganetespib (STA-9090) is a potent synthetic small molecule inhibitor of Hsp90 with potential antineoplastic activity. |
M1949 | Onalespib (AT13387) | Onalespib (AT13387) is a novel, high-affinity heat-shock protein 90 (HSP90) inhibitor with IC50 of 18 nM in A375 cells. |
M1908 | NVP-BEP800 | NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor of Hsp90β with an IC50 of 58 nM. |
M1762 | Luminespib (AUY922) | Luminespib (AUY922) is a small molecule Heat Shock Protein 90 (HSP90) inhibitor with IC50 values of 13 and 21 nM for HSP90α and HSP90β respectively. |
M1679 | BIIB021 | BIIB021 (CNF2024) is an orally available synthetic non-ansamycin Hsp90 inhibitor with ki value of 1.7nM. |
M54514 | Hsp70-derived octapeptide | Hsp70-derived octapeptide is a conserved octapeptide of the C-terminal end of Hsp70, which physically interacts with tetratricopeptide repeat (TPR) motifs. |
M53350 | p5 Ligand for Dnak and DnaJ | p5 Ligand for Dnak and DnaJ is a nonapeptide, which corresponds to the main binding site for the 23-residue part of the presequence of mitochondrial aspartate aminotransferase. |
M50239 | Tertomotide hydrochloride | Tertomotide hydrochloride is a peptide consisting of 16 amino acids containing sequences derived from human telomerase reverse transcriptase (TERT).Tertomotide penetrates cells and interacts with HSP70 and HSP90, as well as inhibiting amyloid beta and tau, and inhibiting aging-related signaling in the brain. pathways, which could be used in aging and Alzheimer's disease related studies. |
M50182 | BMS-986263 | BMS-986263 is a small interfering RNA (siRNA) that targets Hsp47 and can be used in studies related to idiopathic pulmonary fibrosis (IPF). |
M49521 | AT-533 | AT-533 is a potent Hsp90 and HSV inhibitor. |
M49353 | TT-01 | TT-01 is a compound that targets HSP70 and can be used in studies related to vitiligo. |
M43415 | PROTAC Hsp90α degrader 1 | PROTAC Hsp90α degrader 1 is a selective PROTAC Hsp90α degrader. |
M41514 | HSP90-IN-20 | HSP90-IN-20 is a potent HSP90 inhibitor with an IC50 of ≤10 μM. |
M41513 | TRC051384 hydrochloride | TRC051384 hydrochloride is a potent inducer of heat shock protein 70 (HSP70). |
M41512 | TRAP1-IN-1 | TRAP1-IN-1 is a potent and selective inhibitor of TRAP1, a mitochondrial isoform of Hsp90. |
M41511 | HSP90-IN-23 | HSP90-IN-23 is an inhibitor of heat shock protein 90(HSP90) with an IC50 of 9 nM. |
M41510 | Conglobatin | Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. |
M41509 | TRAP1-IN-2 | TRAP1-IN-2 is a selective TRAP1 client protein degrader, while TRAP1-IN-2 is useless for Hsp90-cytosolic clients. |
M41508 | HSP90-IN-22 | HSP90-IN-22 is an Hsp90 inhibitor with antiproliferative properties on cells with IC50 values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively. |
M38928 | Feretoside | Feretoside, a phenolic compound extracted from the barks of E. ulmoides, is a HSP inducer which act as cytoprotective agent. |
M38927 | 10,11-Dehydrocurvularin | 10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity. |
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