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HSP Heat shock proteins

Cat.No.  Name Information
M1725 CUDC-305 CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class.
M7575 Apoptozole Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
M9899 Arimoclomol maleate Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C).
M9273 HSP70-IN-1 HSP70-IN-1 is a heat shock protein (HSP) inhibitor with an IC50 of 2.3 μM inhibiting the growth of Kasumi-1 cells.
M1798 NVP-HSP990 NVP-HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.
M1741 Ganetespib Ganetespib (STA-9090) is a potent synthetic small molecule inhibitor of Hsp90 with potential antineoplastic activity.
M1949 Onalespib (AT13387) Onalespib (AT13387) is a novel, high-affinity heat-shock protein 90 (HSP90) inhibitor with IC50 of 18 nM in A375 cells.
M1908 NVP-BEP800 NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor of Hsp90β with an IC50 of 58 nM.
M1762 Luminespib (AUY922) Luminespib (AUY922) is a small molecule Heat Shock Protein 90 (HSP90) inhibitor with IC50 values of 13 and 21 nM for HSP90α and HSP90β respectively.
M1679 BIIB021 BIIB021 (CNF2024) is an orally available synthetic non-ansamycin Hsp90 inhibitor with ki value of 1.7nM.
M54514 Hsp70-derived octapeptide Hsp70-derived octapeptide is a conserved octapeptide of the C-terminal end of Hsp70, which physically interacts with tetratricopeptide repeat (TPR) motifs.
M53350 p5 Ligand for Dnak and DnaJ p5 Ligand for Dnak and DnaJ is a nonapeptide, which corresponds to the main binding site for the 23-residue part of the presequence of mitochondrial aspartate aminotransferase.
M50239 Tertomotide hydrochloride Tertomotide hydrochloride is a peptide consisting of 16 amino acids containing sequences derived from human telomerase reverse transcriptase (TERT).Tertomotide penetrates cells and interacts with HSP70 and HSP90, as well as inhibiting amyloid beta and tau, and inhibiting aging-related signaling in the brain. pathways, which could be used in aging and Alzheimer's disease related studies.
M50182 BMS-986263 BMS-986263 is a small interfering RNA (siRNA) that targets Hsp47 and can be used in studies related to idiopathic pulmonary fibrosis (IPF).
M49521 AT-533 AT-533 is a potent Hsp90 and HSV inhibitor.
M49353 TT-01 TT-01 is a compound that targets HSP70 and can be used in studies related to vitiligo.
M43415 PROTAC Hsp90α degrader 1 PROTAC Hsp90α degrader 1 is a selective PROTAC Hsp90α degrader.
M41514 HSP90-IN-20 HSP90-IN-20 is a potent HSP90 inhibitor with an IC50 of ≤10 μM.
M41513 TRC051384 hydrochloride TRC051384 hydrochloride is a potent inducer of heat shock protein 70 (HSP70).
M41512 TRAP1-IN-1 TRAP1-IN-1 is a potent and selective inhibitor of TRAP1, a mitochondrial isoform of Hsp90.
M41511 HSP90-IN-23 HSP90-IN-23 is an inhibitor of heat shock protein 90(HSP90) with an IC50 of 9 nM.
M41510 Conglobatin Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus.
M41509 TRAP1-IN-2 TRAP1-IN-2 is a selective TRAP1 client protein degrader, while TRAP1-IN-2 is useless for Hsp90-cytosolic clients.
M41508 HSP90-IN-22 HSP90-IN-22 is an Hsp90 inhibitor with antiproliferative properties on cells with IC50 values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively.
M38928 Feretoside Feretoside, a phenolic compound extracted from the barks of E. ulmoides, is a HSP inducer which act as cytoprotective agent.
M38927 10,11-Dehydrocurvularin 10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity.




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