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IPI-504 hydrochloride

Cat. No. M2777
IPI-504 hydrochloride Structure
Synonym:

Retaspimycin hydrochloride; IPI-504 hcl

Size Price Availability
10mg USD 300  USD300 Custom Synthesis
25mg USD 600  USD600 Custom Synthesis
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Quality Control & Documentation
Biological Activity

IPI-504 (Retaspimycin) hydrochloride is a potent inhibitor of HSP90 with EC50 of 63 nM.

Chemical Information
Molecular Weight 624.17
Formula C31H45N3O8.HCl
CAS Number 857402-63-2
Solubility (25°C) 1M HCl: 90 mg/mL
DMSO: 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Andrew J Wagner, et al. A phase I study of the HSP90 inhibitor retaspimycin hydrochloride (IPI-504) in patients with gastrointestinal stromal tumors or soft-tissue sarcomas

[2] David Siegel, et al. A phase 1 study of IPI-504 (retaspimycin hydrochloride) in patients with relapsed or relapsed and refractory multiple myeloma

[3] William K Oh, et al. Multicenter phase II trial of the heat shock protein 90 inhibitor, retaspimycin hydrochloride (IPI-504), in patients with castration-resistant prostate cancer

[4] Britt Erika Hanson, et al. Retaspimycin hydrochloride (IPI-504): a novel heat shock protein inhibitor as an anticancer agent

[5] Jens R Sydor, et al. Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90

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Keywords: IPI-504 hydrochloride, Retaspimycin hydrochloride; IPI-504 hcl supplier, HSP, inhibitors, activators

 
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