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About 30 results found for searched term "HSP" (0.012 seconds)
| Cat.No. | Name | Information |
|---|---|---|
| M1679 | BIIB021 | BIIB021 (CNF2024) is an orally available synthetic non-ansamycin Hsp90 inhibitor with ki value of 1.7nM. |
| M1725 | CUDC-305 | CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class. |
| M1741 | Ganetespib | Ganetespib (STA-9090) is a potent synthetic small molecule inhibitor of Hsp90 with potential antineoplastic activity. |
| M1762 | Luminespib (AUY922) | Luminespib (AUY922) is a small molecule Heat Shock Protein 90 (HSP90) inhibitor with IC50 values of 13 and 21 nM for HSP90α and HSP90β respectively. |
| M1798 | NVP-HSP990 | NVP-HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. |
| M1908 | NVP-BEP800 | NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor of Hsp90β with an IC50 of 58 nM. |
| M1949 | Onalespib (AT13387) | Onalespib (AT13387) is a novel, high-affinity heat-shock protein 90 (HSP90) inhibitor with IC50 of 18 nM in A375 cells. |
| M2003 | PF-04929113 | PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor with Kd of 41 nM. |
| M2070 | XL888 | XL888 is a novel small-molecule inhibitor of HSP90 with IC50 of 24 nM. |
| M2320 | 17-AAG (Tanespimycin) | 17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM. |
| M2321 | 17-DMAG (Alvespimycin) hydrochloride | 17-DMAG (Alvespimycin, KOS-1022, NSC 707545) hydrochloride is a potent HSP90 inhibitor with IC50 of 62 nM. |
| M2776 | IPI-493 | IPI-493 is a potent and orally bioavailable HSP90 inhibitor with Ki of 21 nM. |
| M2777 | IPI-504 hydrochloride | IPI-504 (Retaspimycin) hydrochloride is a potent inhibitor of HSP90 with EC50 of 63 nM. |
| M2885 | NMS-E973 | NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases. |
| M2943 | Pifithrin-μ | Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy. |
| M3116 | VER 155008 | VER-155008 is a potent inhibitor of the HSP70 family, with IC50 of 0.5 μM and 2.6 μM for HSP70 and Grp78, respectively, exhibits >100-fold selectivity over HSP90. |
| M3117 | VER-49009 | VER-49009 is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β. |
| M3197 | MPC-3100 | MPC-3100 is a fully synthetic and potent Hsp90 inhibitor with IC50 of 60 nM. |
| M3528 | SNX-2112 | SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG. |
| M3561 | Geldanamycin | Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. |
| M3563 | KW-2478 | KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. |
| M3683 | Retaspimycin | Retaspimycin is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). |
| M3776 | CH5138303 | CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM. |
| M4618 | Eupalinolide A | Eupalinolide A, isolated from Eupatorium lindleyanum, induces the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90. |
| M4771 | Dihydroberberine | Dihydroberberine inhibited the human Ether-related gene (hERG) channel and significantly reduced the expression of heat shock protein 90 (Hsp90) and its interaction with hERG. Dihydroberberine has anti-inflammatory, antiatherosclerotic, hylipidemic and antitumor activities. |
| M6075 | HA15 | HA15 is a molecule that targets specifically BiP/GRP78/HSPA5. HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. |
| M6512 | BIX | BIX is a biP (Hsp70-5) ER chaperone inducer. |
| M6571 | CCT 018159 | CCT 018159 is a hsp90 inhibitor. |
| M6697 | EC 144 | EC 144 is a high affinity, potent and selective Hsp90 inhibitor. |
| M7185 | Radicicol | Radicicol is a hsp90 inhibitor. Antifungal antibiotic. |
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