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VER-49009

Cat. No. M3117

All AbMole products are for research use only, cannot be used for human consumption.

VER-49009 Structure
Synonym:

CCT0129397

Size Price Availability Quantity
1mg USD 75  USD75 In stock
5mg USD 225  USD225 In stock
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Quality Control & Documentation
Biological Activity

VER-49009 is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β.

Protocol (for reference only)
Cell Experiment
Cell lines Melanoma cells (SKMEL 2, SKMEL 5, SKMEL 28, WM266.4); Colon cancer cells (HCT116, BEneg, BE2, HT29, HT29oxaliR); Ovarian cancer cells (CH1, CH1doxR); Breast cancer cells (MB-231, MB-468, BT20, ZR751, MCF7, BT-474); nontumorigenic cells (HUVEC, MCF10a, PNT
Preparation method Using the sulforhodamine B assay to mearsure antiproliferative effects . Determining HUVEC sensitivity by an alkaline phosphatase method.
Concentrations ~10 μM
Incubation time 4 days
Animal Experiment
Animal models Mice bearing established OVCAR3 human ovarian xenografts
Formulation 10% DMSO, 5% Tween 20, 85% saline
Dosages ~4 mg/kg
Administration i.p.
Chemical Information
Molecular Weight 387.82
Formula C19H18ClN3O4
CAS Number 940289-57-6
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Chul-Ho Jeong, et al. Discovery of hybrid Hsp90 inhibitors and their anti-neoplastic effects against gefitinib-resistant non-small cell lung cancer (NSCLC)

[2] Xu Sun, et al. Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro

[3] Nathalie Gaspar, et al. Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells

[4] Swee Y Sharp, et al. Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

[5] Xavier Barril, et al. 4-Amino derivatives of the Hsp90 inhibitor CCT018159

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  Catalog
Abmole Inhibitor Catalog




Keywords: VER-49009, CCT0129397 supplier, HSP, inhibitors, activators

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