| Cat.No. | Name | Information |
|---|---|---|
| M1725 | CUDC-305 | CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class. |
| M7575 | Apoptozole | Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis. |
| M9899 | Arimoclomol maleate | Arimoclomol maleate (also known as BRX-220) is a heat shock protein amplifier, and is potentially useful for the treatment of Niemann-Pick disease type C (NP-C). |
| M9273 | HSP70-IN-1 | HSP70-IN-1 is a heat shock protein (HSP) inhibitor with an IC50 of 2.3 μM inhibiting the growth of Kasumi-1 cells. |
| M1798 | NVP-HSP990 | NVP-HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively. NVP-HSP990 has potential antineoplastic activity. |
| M1741 | Ganetespib | Ganetespib (STA-9090) is a potent synthetic small molecule inhibitor of Hsp90 with potential antineoplastic activity. |
| M2320 | 17-AAG (Tanespimycin) | 17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM. |
| M41513 | TRC051384 hydrochloride | TRC051384 hydrochloride is a potent inducer of heat shock protein 70 (HSP70). |
| M41512 | TRAP1-IN-1 | TRAP1-IN-1 is a potent and selective inhibitor of TRAP1, a mitochondrial isoform of Hsp90. |
| M41511 | HSP90-IN-23 | HSP90-IN-23 is an inhibitor of heat shock protein 90(HSP90) with an IC50 of 9 nM. |
| M41510 | Conglobatin | Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. |
| M41509 | TRAP1-IN-2 | TRAP1-IN-2 is a selective TRAP1 client protein degrader, while TRAP1-IN-2 is useless for Hsp90-cytosolic clients. |
| M41508 | HSP90-IN-22 | HSP90-IN-22 is an Hsp90 inhibitor with antiproliferative properties on cells with IC50 values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively. |
| M38928 | Feretoside | Feretoside, a phenolic compound extracted from the barks of E. ulmoides, is a HSP inducer which act as cytoprotective agent. |
| M38927 | 10,11-Dehydrocurvularin | 10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity. |
| M31376 | DN401 | DN401 is a potent TRAP1 and Hsp90 inhibitor with anticancer activity with IC50 values of 79 nM and 698 nM, respectively. |
| M30607 | BOLD-100 free base | BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution. |
| M30058 | YM-1 | YM-1 is a stable and soluble MKT-077 analog and an orally active Hsp70 inhibitor. YM-1 induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins. |
| M29735 | Azadiradione | Azadiradione is a bioactive limonoid found in Azadirachta indica. Azadiradione is a HSF1 activator. Azadiradione has antimycobacterial, anti-nociceptive and anti-inflammatory activities. |
| M29721 | SEW84 | IC50: 0.3 μM (ASH); 1.3 μM (GR-dependent luciferase expression); 0.7 μM (AR-dependent luciferase expression)[1] |
| M29527 | DDO-5936 | DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer. |
| M28960 | CPUY201112 | CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research. |
| M28763 | YZ129 | YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration. |
| M28715 | JG-231 | JG-231 is an analogue of JG-98 with anticancer effects. JG-231 inhibits the interaction of Hsp70-BAG3. JG-231 inhibits MDA-MB-231 heterograft tumor models of triple negative breast cancer (TNBC). |
| M28600 | HS-27 | HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90. HS-27 has potential use in a see-and-treat paradigm in breast cancer. |
| M28488 | PU-H54 | PU-H54, a Grp94-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy. |
| M28403 | HSP70-IN-4 | HSP70-IN-4 (Compound YM-01) is an Hsp70 inhibitor with an IC50 of 3.2 μM. HSP70-IN-4 is not BBB permeable. |
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