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Conglobatin

Cat. No. M41510
Conglobatin Structure
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Biological Activity

Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus.

Chemical Information
Molecular Weight 498.61
Formula C28H38N2O6
CAS Number 72263-05-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Heather Lacey et al. J Antibiot (Tokyo). Yeppoonic acids A - D: 1,2,4-trisubstituted arene carboxylic acid co-metabolites of conglobatin from an Australian Streptomyces sp

[2] Zhiran Ju et al. ACS Chem Biol. Modulation of Specialized Metabolite Production in Genetically Engineered Streptomyces pactum

[3] Heather J Lacey et al. J Antibiot (Tokyo). Conglobatins B-E: cytotoxic analogues of the C2-symmetric macrodiolide conglobatin

[4] Yongjun Zhou et al. Chem Biol. Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin

[5] J W Westley et al. J Antibiot (Tokyo). Conglobatin, a novel macrolide dilactone from Streptomyces conglobatus ATCC 31005

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