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YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity. YUM70 induces endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer.
YUM70 (30 mg/kg; intraperitoneal injection, 5 days/week for 7 weeks) inhibits tumor growth in MIA PaCa-2 xenograft model.
| Molecular Weight | 398.84 |
| Formula | C21H19ClN2O4 |
| CAS Number | 423145-35-1 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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