Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90).
|Solubility (25°C)||DMSO ≥ 60 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Ruiying Wang, et al. J Adv Res. Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate myocardial ischemia/reperfusion injury
 Ruiying Wang, et al. Biomed Pharmacother. Calenduloside E protects against myocardial ischemia-reperfusion injury induced calcium overload by enhancing autophagy and inhibiting L-type Ca 2+ channels through BAG3
 Tuo Tang, et al. Nan Fang Yi Ke Da Xue Xue Bao. [Calenduloside E inhibits lipopolysaccharide-induced inflammatory response by inhibiting activation of ROS-mediated JAK1-stat3 signaling pathway in RAW264.7 cells]
|Related HSP Products|
|PROTAC Hsp90α degrader 1
PROTAC Hsp90α degrader 1 is a selective PROTAC Hsp90α degrader.
HSP90-IN-20 is a potent HSP90 inhibitor with an IC50 of ≤10 μM.
TRC051384 hydrochloride is a potent inducer of heat shock protein 70 (HSP70).
TRAP1-IN-1 is a potent and selective inhibitor of TRAP1, a mitochondrial isoform of Hsp90.
HSP90-IN-23 is an inhibitor of heat shock protein 90(HSP90) with an IC50 of 9 nM.
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