Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90).
| Molecular Weight | 632.82 |
| Formula | C36H56O9 |
| CAS Number | 26020-14-4 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related HSP Products |
|---|
| PROTAC Hsp90α degrader 1
PROTAC Hsp90α degrader 1 is a selective PROTAC Hsp90α degrader. |
| HSP90-IN-20
HSP90-IN-20 is a potent HSP90 inhibitor with an IC50 of ≤10 μM. |
| TRC051384 hydrochloride
TRC051384 hydrochloride is a potent inducer of heat shock protein 70 (HSP70). |
| TRAP1-IN-1
TRAP1-IN-1 is a potent and selective inhibitor of TRAP1, a mitochondrial isoform of Hsp90. |
| HSP90-IN-23
HSP90-IN-23 is an inhibitor of heat shock protein 90(HSP90) with an IC50 of 9 nM. |
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