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JG-98 is an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 (10 μM) activates apoptotic mediators (cleavage of caspase-3 and PARP) in MDA-MB-231 cells. In vivo, JG-98 (3 mg/kg; ip) suppresses tumor growth in xenograft models bearing MCF7 and HeLa cells.
| Molecular Weight | 534.54 |
| Formula | C24H21Cl2N3OS3 |
| CAS Number | 1456551-16-8 |
| Solubility (25°C) | DMSO 4 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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| Hsp70-derived octapeptide
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