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Bcl-2 B-cell lymphoma 2

Inhibitors

Cat.No.  Name Information
M1637 ABT-263 ABT-263 (Navitoclax) is a potent, orally bioavailable inhibitor of the antiapoptotic Bcl-2 family members Bcl-2, Bcl-x (L), and Bcl-w.
M2017 ABT-199 (Venetoclax) ABT-199 is a highly potent, orally bioavailable and BCL-2 inhibitor. ABT-199 is the first inhibitor targeting Bcl-2 and PPI.
M5273 S63845 S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor; binds human MCL1 with a Kd of 0.19 nM.
M13534 WEHI-539 hydrochloride WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL with an IC50 of 1.1 nM.
M13533 S55746 hydrochloride S55746 hydrochloride (BCL201 hydrochloride) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 hydrochloride (BCL201 hydrochloride) has antitumor activity with low toxicity.
M13532 S55746 S55746 (BCL201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BCL201) has antitumor activity with low toxicity.
M13531 Dehydrocorydaline nitrate Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid.
M13530 Dehydrocorydaline chloride Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP.
M13529 BAI1 BAI1 is a selective and allosteric inhibitor of BAX, an apoptosis regulator. BAI1 directly binds to BAX and allosterically inhibits BAX activation. BAI1 has the potential for the research of diseases mediated by BAX-dependent cell death.
M13528 AZD-5991 AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay.
M13527 (R)-(-)-Gossypol acetic acid (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol.
M13526 A-1155463 A-1155463 is a highly potent and selective BCL-XL inhibitor with an EC50 of 70 nM in Molt-4 cell.
M13525 (S)-Gossypol (acetic acid) (S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.
M13381 Pyridoclax Pyridoclax is a potential McL-1 inhibitor.
M13380 Tapotoclax Tapotoclax is an inhibitor of myeloid leukemia cell differentiation protein McL-1 (myeloid leukemia-1) with a Ki value of 0.13 nM and has potential pro-apoptotic and anti-tumor activity.
M10283 AZD-5991 Racemate AZD-5991 Racemate is a Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay.
M9419 Bax inhibitor peptide V5 Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor.
M9095 Marinopyrrole A Marinopyrrole A (Maritoclax) is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM.
M9044 MIK665 MIK665 is an inhibitor of induced myeloid leukemia cell differentiation protein (Mcl-1; Bcl2-L-3).
M8920 BDA-366 BDA-366 is a small molecule antagonist that specifically binds the BCL2 BH4 domain, and has the ability to convert anti-apoptotic BCL2 into a pro-apoptotic death molecule.
M7548 A-1331852 A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM.
M6256 BTSA1 BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells.
M5273 S63845 S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor; binds human MCL1 with a Kd of 0.19 nM.



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